UGT1A1*6, UGT1A7*3 and UGT1A9*1b polymorphisms are predictive markers for severe toxicity in patients with metastatic gastrointestinal cancer treated with irinotecan-based regimens

  • Authors:
    • Chengxu Cui
    • Chang Shu
    • Dandan Cao
    • Yi Yang
    • Junbao Liu
    • Shuping Shi
    • Zhujun Shao
    • Nan Wang
    • Ting Yang
    • Hao Liang
    • Shanshan Zou
    • Songnian Hu
  • View Affiliations

  • Published online on: September 14, 2016     https://doi.org/10.3892/ol.2016.5130
  • Pages: 4231-4237
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Abstract

Irinotecan-induced severe neutropenia and diarrhea, which remain unpredictable, has restrained the dose and clinical efficiency of irinotecan administration. In the present study, a total of 70 irinotecan-treated patients with histologically confirmed metastatic gastrointestinal cancer were enrolled. Despite genotyping well‑reported alleles, direct sequencing was specifically adopted to avoid ethnic heterogeneity and to identify novel variations. The promoter (‑1000 bp) and exon 1 regions of UDP glucuronosyltransferase family 1 member A complex locus (UGT1A1) gene family members UGT1A1, UGT1A7 and UGT1A9 were sequenced, and comprehensive analysis of their genetic polymorphisms was performed to determine the association between inherited genetic variations and irinotecan‑induced toxicity. A total of 23 different genetic variants were detected in the present study, including 2 novel polymorphisms. The results of the present study revealed that UGT1A1*6 and UGT1A7*3 are risk factors for irinotecan‑induced severe neutropenia, and UGT1A9*1b is associated with severe diarrhea. These results may provide biomarkers for the selection of the optimal chemotherapy for Chinese patients with metastatic gastrointestinal cancer.
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November-2016
Volume 12 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Cui C, Shu C, Cao D, Yang Y, Liu J, Shi S, Shao Z, Wang N, Yang T, Liang H, Liang H, et al: UGT1A1*6, UGT1A7*3 and UGT1A9*1b polymorphisms are predictive markers for severe toxicity in patients with metastatic gastrointestinal cancer treated with irinotecan-based regimens. Oncol Lett 12: 4231-4237, 2016.
APA
Cui, C., Shu, C., Cao, D., Yang, Y., Liu, J., Shi, S. ... Hu, S. (2016). UGT1A1*6, UGT1A7*3 and UGT1A9*1b polymorphisms are predictive markers for severe toxicity in patients with metastatic gastrointestinal cancer treated with irinotecan-based regimens. Oncology Letters, 12, 4231-4237. https://doi.org/10.3892/ol.2016.5130
MLA
Cui, C., Shu, C., Cao, D., Yang, Y., Liu, J., Shi, S., Shao, Z., Wang, N., Yang, T., Liang, H., Zou, S., Hu, S."UGT1A1*6, UGT1A7*3 and UGT1A9*1b polymorphisms are predictive markers for severe toxicity in patients with metastatic gastrointestinal cancer treated with irinotecan-based regimens". Oncology Letters 12.5 (2016): 4231-4237.
Chicago
Cui, C., Shu, C., Cao, D., Yang, Y., Liu, J., Shi, S., Shao, Z., Wang, N., Yang, T., Liang, H., Zou, S., Hu, S."UGT1A1*6, UGT1A7*3 and UGT1A9*1b polymorphisms are predictive markers for severe toxicity in patients with metastatic gastrointestinal cancer treated with irinotecan-based regimens". Oncology Letters 12, no. 5 (2016): 4231-4237. https://doi.org/10.3892/ol.2016.5130