Primary renal lymphoma: A case report and literature review

Chen,Xiaodong; Hu,Danfei; Fang,Laifu; Chen,Yichen; Che,Xiaohang; Tao,Jin; Weng,Guobin; Ye,Xiaolei

doi:10.3892/ol.2016.5173

Primary renal lymphoma: A case report and literature review

Authors:
- Xiaodong Chen
- Danfei Hu
- Laifu Fang
- Yichen Chen
- Xiaohang Che
- Jin Tao
- Guobin Weng
- Xiaolei Ye
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Affiliations: Department of Urology, Ningbo Urology and Nephrology Hospital, Ningbo University, Ningbo, Zhejiang 315100, P.R. China, Department of Radiation Therapy, Ningbo Medical Treatment Center Lihuili Hospital, Ningbo, Zhejiang 315020, P.R. China, Department of Pathology, Ningbo Yin Zhou Hospital, Ningbo, Zhejiang 315020, P.R. China, Division of Drugs and Pharmacology, Ningbo Institute of Medical Sciences, Ningbo, Zhejiang 315020, P.R. China
Published online on: September 22, 2016 https://doi.org/10.3892/ol.2016.5173
Pages: 4001-4008

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Abstract

Primary renal lymphoma (PRL) is a rare disease, with no more than 70 cases reported in the literature. The present study reports the case of a 70‑year‑old woman with PRL. The patient was asymptomatic, however, a mass on the right kidney was identified incidentally during routine physical examination. Computed tomography revealed a mass in the right kidney that was 3.6 cm in diameter. Subsequently, right nephrectomy was performed. The histological evaluation of the nephrectomy specimen showed diffuse large B‑cell non‑Hodgkin's lymphoma. The patient was treated with 6-8 cycles of a cyclophosphamide, epirubicin, vindesine and dexamethasone regimen. Follow-up examination performed after 2 months of treatment revealed no evidence of local recurrence. The present study also reviewed 49 cases of PRL that have been reported since 1989. It was found that a shorter survival time was experienced by patients with bilateral PRL (mean, 21 months) compared with unilateral PRL (mean, 68 months). A shorter survival time was also experienced by patients who were treated with chemotherapy only (mean, 15.8 months) compared with those who were treated with combination chemotherapy and surgery (mean, 49.4 months).

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