A complex translocation (3;17;15) in acute promyelocytic leukemia confirmed by fluorescence in situ hybridization

  • Authors:
    • Yanming Wang
    • Junjie Ma
    • Xinguang Liu
    • Riming Liu
    • Lingling Xu
    • Li Wang
    • Jiannong Cen
    • Xiaoxia Chu
  • View Affiliations

  • Published online on: October 18, 2016     https://doi.org/10.3892/ol.2016.5280
  • Pages: 4717-4719
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Acute promyelocytic leukemia (APL) is typified by t(15;17)(q22;q21), generating the promyelocytic leukemia (PML) gene at 15q22 with the retinoic acid α‑receptor (RARA) gene at 17q21. The PML‑RARA fusion gene is believed to play a vital role in leukemogenesis. A sizeable minority of patients with complex variants of APL have been reported. The present study reports the case of a 33‑year‑old male with APL carrying a potential complex translocation. The initial symptom was bleeding gums. Chromosomal analysis of the bone marrow cells revealed an atypical 17q aberration. Fluorescence in situ hybridization further indicated that 92% of analyzed cells were positive for the PML‑RARA fusion gene. The patient experienced complete remission following treatment with arsenic trioxide and chemotherapy. The atypical translocations in acute promyelocytic leukemia require further investigation.
View Figures
View References

Related Articles

Journal Cover

December-2016
Volume 12 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Ma J, Liu X, Liu R, Xu L, Wang L, Cen J and Chu X: A complex translocation (3;17;15) in acute promyelocytic leukemia confirmed by fluorescence in situ hybridization. Oncol Lett 12: 4717-4719, 2016.
APA
Wang, Y., Ma, J., Liu, X., Liu, R., Xu, L., Wang, L. ... Chu, X. (2016). A complex translocation (3;17;15) in acute promyelocytic leukemia confirmed by fluorescence in situ hybridization. Oncology Letters, 12, 4717-4719. https://doi.org/10.3892/ol.2016.5280
MLA
Wang, Y., Ma, J., Liu, X., Liu, R., Xu, L., Wang, L., Cen, J., Chu, X."A complex translocation (3;17;15) in acute promyelocytic leukemia confirmed by fluorescence in situ hybridization". Oncology Letters 12.6 (2016): 4717-4719.
Chicago
Wang, Y., Ma, J., Liu, X., Liu, R., Xu, L., Wang, L., Cen, J., Chu, X."A complex translocation (3;17;15) in acute promyelocytic leukemia confirmed by fluorescence in situ hybridization". Oncology Letters 12, no. 6 (2016): 4717-4719. https://doi.org/10.3892/ol.2016.5280