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Article

Expression of cancerous inhibitor of protein phosphatase 2A in human triple negative breast cancer correlates with tumor survival, invasion and autophagy

Corrigendum in: /10.3892/ol.2025.15047
  • Authors:
    • Shan Li
    • Ting‑Ting Feng
    • Yang Guo
    • Xianjun Yu
    • Qiuyue Huang
    • Liang Zhang
    • Wei Tang
    • Ying Liu
  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry, School of Basic Medical Sciences, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China, School of Basic Medical Sciences, Anhui Medical University, Heifei, Anhui 230032, P.R. China
  • Pages: 5370-5376
    |
    Published online on: November 9, 2016
       https://doi.org/10.3892/ol.2016.5374
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Abstract

Cancerous inhibitor of protein phosphatase 2A (CIP2A) is a recently characterized oncoprotein which is involved in the progression of several human malignancies. The present study aimed to investigate its biological function in human triple negative breast cancer (TNBC). The expression of CIP2A in TNBC cells was examined and it was observed that CIP2A was elevated in the TNBC cell line compared with poorly invasive breast cancer cells. CIP2A depletion in TNBC cell lines inhibited proliferation, and induced apoptosis and autophagy. In addition, CIP2A depletion inhibited invasion and migration of TNBC cells. Furthermore, CIP2A depletion downregulated Akt/mTOR/P70S6K phosphorylation. These results validate the role of CIP2A as a invasion‑associated oncoprotein and established CIP2A as a promising therapeutic target of TNBC.
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1 

DeSantis C, Ma J, Bryan L and Jemal A: Breast cancer statistics, 2013. CA Cancer J Clin. 64:52–62. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Yaman S, Gumuskaya B, Ozkan C, Aksoy S, Guler G and Altundag K: Lymphatic and capillary invasion patterns in triple negative breast cancer. Am Surg. 78:1238–1242. 2012.PubMed/NCBI

3 

Junttila MR, Puustinen P, Niemelä M, Ahola R, Arnold H, Böttzauw T, Ala-aho R, Nielsen C, Ivaska J, Taya Y, et al: CIP2A inhibits PP2A in human malignancies. Cell. 130:51–62. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Li W, Ge Z, Liu C, Björkholm M, Jia J and Xu D: CIP2A is overexpressed in gastric cancer and its depletion leads to impaired clonogenicity, senescence, or differentiation of tumor cells. Clin Cancer Res. 14:3722–3728. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Ma L, Wen ZS, Liu Z, Hu Z, Ma J, Chen XQ, Liu YQ, Pu JX, Xiao WL, Sun HD and Zhou GB: Overexpression and small molecule-triggered downregulation of CIP2A in lung cancer. PLoS One. 6:e201592011. View Article : Google Scholar : PubMed/NCBI

6 

Ren J, Li W, Yan L, Jiao W, Tian S, Li D, Tang Y, Gu G, Liu H and Xu Z: Expression of CIP2A in renal cell carcinomas correlates with tumour invasion, metastasis and patients' survival. Br J Cancer. 105:1905–1911. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Wang J, Li W, Li L, Yu X, Jia J and Chen C: CIP2A is over-expressed in acute myeloid leukaemia and associated with HL60 cells proliferation and differentiation. Int J Lab Hematol. 33:290–298. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Lucas CM, Harris RJ, Giannoudis A, Copland M, Slupsky JR and Clark RE: Cancerous inhibitor of PP2A (CIP2A) at diagnosis of chronic myeloid leukemia is a critical determinant of disease progression. Blood. 117:6660–6668. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Liu Z, Ma L, Wen ZS, Hu Z, Wu FQ, Li W, Liu J and Zhou GB: Cancerous inhibitor of PP2A is targeted by natural compound celastrol for degradation in non-small-cell lung cancer. Carcinogenesis. 35:905–914. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Côme C, Laine A, Chanrion M, Edgren H, Mattila E, Liu X, Jonkers J, Ivaska J, Isola J, Darbon JM, et al: CIP2A is associated with human breast cancer aggressivity. Clin Cancer Res. 15:5092–5100. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Tseng LM, Liu CY, Chang KC, Chu PY, Shiau CW and Chen KF: CIP2A is a target of bortezomib in human triple negative breast cancer cells. Breast Cancer Res. 14:R682012. View Article : Google Scholar : PubMed/NCBI

12 

Chen KF, Liu CY, Lin YC, Yu HC, Liu TH, Hou DR, Chen PJ and Cheng AL: CIP2A mediates effects of bortezomib on phospho-Akt and apoptosis in hepatocellular carcinoma cells. Oncogene. 29:6257–6266. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Memmott RM and Dennis PA: Akt-dependent and -independent mechanisms of mTOR regulation in cancer. Cell Signal. 21:656–664. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Liu Y, Cao W, Zhang B, Liu YQ, Wang ZY, Wu YP, Yu XJ, Zhang XD, Ming PH, Zhou GB and Huang L: The natural compound magnolol inhibits invasion and exhibits potential in human breast cancer therapy. Sci Rep. 3:30982013.PubMed/NCBI

15 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

16 

Liu B, Han M, Sun RH, Wang JJ, Zhang YP, Zhang DQ and Wen JK: ABL-N-induced apoptosis in human breast cancer cells is partially mediated by c-Jun NH2-terminal kinase activation. Breast Cancer Research. 12:R92010. View Article : Google Scholar : PubMed/NCBI

17 

Liu Y, Chen XQ, Liang HX, Zhang FX, Zhang B, Jin J, Chen YL, Cheng YX and Zhou GB: Small compound 6-O-angeloylplenolin induces mitotic arrest and exhibits therapeutic potentials in multiple myeloma. PLoS One. 6:e219302011. View Article : Google Scholar : PubMed/NCBI

18 

Zhang B, Jiao J, Liu Y, Guo LX, Zhou B, Li GQ, Yao ZJ and Zhou GB: Gefitinib analogue V1801 induces apoptosis of T790M egfr-harboring lung cancer cells by up-regulation of the BH-3 only protein noxa. PLoS One. 7:e487482012. View Article : Google Scholar : PubMed/NCBI

19 

Lee J, Park EJ, Hwang JW, Oh JM, Kim H, Bae EK, Choi YL, Han J, Ahn JK, Cha HS and Koh EM: CIP2A expression is associated with synovial hyperplasia and invasive function of fibroblast-like synoviocytes in rheumatoid arthritis. Rheumatol Int. 32:2023–2030. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Zhai M, Cong L, Han Y and Tu G: CIP2A is overexpressed in osteosarcoma and regulates cell proliferation and invasion. Tumour Biol. 35:1123–1128. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Ha K, Fiskus W, Choi DS, Bhaskara S, Cerchietti L, Devaraj SG, Shah B, Sharma S, Chang JC, Melnick AM, et al: Histone deacetylase inhibitor treatment induces 'BRCAness' and synergistic lethality with PARP inhibitor and cisplatin against human triple negative breast cancer cells. Oncotarget. 5:5637–5650. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Puustinen P, Rytter A, Mortensen M, Moreira JM and Jäättelä M: CIP2A oncoprotein controls cell growth and autophagy through mTORC1 activation. J Cell Biol. 204:713–727. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Guffei A, Lichtensztejn Z, Gonçalves Dos Santos SA, Louis SF, Caporali A and Mai S: c-Myc-dependent formation of Robertsonian translocation chromosomes in mouse cells. Neoplasia. 9:578–588. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Vaqué JP, Fernéndez-García B, García-Sanz P, Ferrandiz N, Bretones G, Calvo F, Crespo P, Marín MC and León J: c-Myc inhibits Ras-mediated differentiation of pheochromocytoma cells by blocking c-Jun up-regulation. Mol Cancer Res. 6:325–339. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Helland A, Anglesio MS, George J, Cowin PA, Johnstone CN, House CM, Sheppard KE, Etemadmoghadam D, Melnyk N, Rustgi AK, et al: Deregulation of MYCN, LIN28B and LET7 in a molecular subtype of aggressive high-grade serous ovarian cancers. PLoS One. 6:e180642011. View Article : Google Scholar : PubMed/NCBI

26 

Ma L, Young J, Prabhala H, Pan E, Mestdagh P, Muth D, Teruya-Feldstein J, Reinhardt F, Onder TT, Valastyan S, et al: miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis. Nat Cell Biol. 12:247–256. 2010.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li S, Feng TT, Guo Y, Yu X, Huang Q, Zhang L, Tang W and Liu Y: Expression of cancerous inhibitor of protein phosphatase 2A in human triple negative breast cancer correlates with tumor survival, invasion and autophagy Corrigendum in /10.3892/ol.2025.15047. Oncol Lett 12: 5370-5376, 2016.
APA
Li, S., Feng, T., Guo, Y., Yu, X., Huang, Q., Zhang, L. ... Liu, Y. (2016). Expression of cancerous inhibitor of protein phosphatase 2A in human triple negative breast cancer correlates with tumor survival, invasion and autophagy Corrigendum in /10.3892/ol.2025.15047. Oncology Letters, 12, 5370-5376. https://doi.org/10.3892/ol.2016.5374
MLA
Li, S., Feng, T., Guo, Y., Yu, X., Huang, Q., Zhang, L., Tang, W., Liu, Y."Expression of cancerous inhibitor of protein phosphatase 2A in human triple negative breast cancer correlates with tumor survival, invasion and autophagy Corrigendum in /10.3892/ol.2025.15047". Oncology Letters 12.6 (2016): 5370-5376.
Chicago
Li, S., Feng, T., Guo, Y., Yu, X., Huang, Q., Zhang, L., Tang, W., Liu, Y."Expression of cancerous inhibitor of protein phosphatase 2A in human triple negative breast cancer correlates with tumor survival, invasion and autophagy Corrigendum in /10.3892/ol.2025.15047". Oncology Letters 12, no. 6 (2016): 5370-5376. https://doi.org/10.3892/ol.2016.5374
Copy and paste a formatted citation
x
Spandidos Publications style
Li S, Feng TT, Guo Y, Yu X, Huang Q, Zhang L, Tang W and Liu Y: Expression of cancerous inhibitor of protein phosphatase 2A in human triple negative breast cancer correlates with tumor survival, invasion and autophagy Corrigendum in /10.3892/ol.2025.15047. Oncol Lett 12: 5370-5376, 2016.
APA
Li, S., Feng, T., Guo, Y., Yu, X., Huang, Q., Zhang, L. ... Liu, Y. (2016). Expression of cancerous inhibitor of protein phosphatase 2A in human triple negative breast cancer correlates with tumor survival, invasion and autophagy Corrigendum in /10.3892/ol.2025.15047. Oncology Letters, 12, 5370-5376. https://doi.org/10.3892/ol.2016.5374
MLA
Li, S., Feng, T., Guo, Y., Yu, X., Huang, Q., Zhang, L., Tang, W., Liu, Y."Expression of cancerous inhibitor of protein phosphatase 2A in human triple negative breast cancer correlates with tumor survival, invasion and autophagy Corrigendum in /10.3892/ol.2025.15047". Oncology Letters 12.6 (2016): 5370-5376.
Chicago
Li, S., Feng, T., Guo, Y., Yu, X., Huang, Q., Zhang, L., Tang, W., Liu, Y."Expression of cancerous inhibitor of protein phosphatase 2A in human triple negative breast cancer correlates with tumor survival, invasion and autophagy Corrigendum in /10.3892/ol.2025.15047". Oncology Letters 12, no. 6 (2016): 5370-5376. https://doi.org/10.3892/ol.2016.5374
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