Role of Annexin A2 in the EGF-induced epithelial-mesenchymal transition in human CaSki cells

  • Authors:
    • Lei Cui
    • Jian Song
    • Liting Wu
    • Luhui Cheng
    • Aijun Chen
    • Yanlin Wang
    • Yingdi Huang
    • Liming Huang
  • View Affiliations

  • Published online on: November 21, 2016     https://doi.org/10.3892/ol.2016.5406
  • Pages: 377-383
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Abstract

The epidermal growth factor receptor (EGF-R) signaling pathway is thought to have an important role in the development and progression of several carcinomas, as it is associated with cell proliferation, differentiation and migration. Activation of EGF-R signaling regulates epithelial-mesenchymal transition (EMT)‑associated invasion and migration in normal and malignant epithelial cells. However, the specific mechanisms have not yet been fully elucidated. The present study utilized wound healing assays, western blotting, flow cytometry and MTT assays to demonstrate that Annexin A2 (ANXA2) is a key regulatory factor in EGF‑induced EMT in CaSki cervical cancer cells. Moreover, the increased expression levels of ANXA2 promoted cell viability and migration in human CaSki cells. It was also found that silencing ANXA2 partially reverses EGF‑induced EMT and inhibits cell viability and migration in CaSki cells. These findings suggest that ANXA2 is a key regulator of EGF‑induced EMT in CaSki cervical cancer cells.
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January-2017
Volume 13 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Cui L, Song J, Wu L, Cheng L, Chen A, Wang Y, Huang Y and Huang L: Role of Annexin A2 in the EGF-induced epithelial-mesenchymal transition in human CaSki cells. Oncol Lett 13: 377-383, 2017.
APA
Cui, L., Song, J., Wu, L., Cheng, L., Chen, A., Wang, Y. ... Huang, L. (2017). Role of Annexin A2 in the EGF-induced epithelial-mesenchymal transition in human CaSki cells. Oncology Letters, 13, 377-383. https://doi.org/10.3892/ol.2016.5406
MLA
Cui, L., Song, J., Wu, L., Cheng, L., Chen, A., Wang, Y., Huang, Y., Huang, L."Role of Annexin A2 in the EGF-induced epithelial-mesenchymal transition in human CaSki cells". Oncology Letters 13.1 (2017): 377-383.
Chicago
Cui, L., Song, J., Wu, L., Cheng, L., Chen, A., Wang, Y., Huang, Y., Huang, L."Role of Annexin A2 in the EGF-induced epithelial-mesenchymal transition in human CaSki cells". Oncology Letters 13, no. 1 (2017): 377-383. https://doi.org/10.3892/ol.2016.5406