search button

Bone metastasis from lung cancer identified by genetic profiling

  • Authors:
    • Zhu‑Lin Liu
    • Chun Wang
    • Hui‑Jiao Chen
    • Xue Li
    • Li‑Jun Dai
    • Zhen‑Yu Ding

  • View Affiliations

  • Published online on: December 2, 2016     https://doi.org/10.3892/ol.2016.5458
  • Pages: 847-850
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Cancer metastasis remains responsible for the vast majority of cases of cancer‑related morbidity and mortality. Metastasis, by its definition, is the spread of cancer from the primary site to the distant tissues. Advancing the scientific and clinical understanding of cancer metastasis is a high priority. The prerequisite requirement for pathological consistency may be compromised during metastasis. The present study reports the case of a cancer patient with different pathological types. The patient presented with pain in the neck and right hip, as well as weight loss. He underwent whole‑body positron emission tomography‑computed tomography, which identified a mass in the lung and abnormal metabolism of the bone. Biopsies of the ilium and lung were performed and he was shown to have lung adenocarcinoma and bone squamous carcinoma. The morphology and immunohistochemical patterns were completely different, while each lesion harbored an identical genetic profile. The bone lesion was identified to be a metastasis from the lung cancer. The patient was prescribed an epithelial growth factor receptor inhibitor, which resulted in a partial response in the lung mass and alleviation of the patient's bone pain. Through this case study, we advocate the importance of using genetic testing in addition to pathological assessment.
View Figures
View References

Related Articles

Journal Cover

February-2017
Volume 13 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

  • Journal Metrics
  • Impact Factor: 2.5
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 5.7
  • CiteScore Rank: Q2: #139/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.574
  • SCImago Journal Rank (SJR): 0.644
International Symposium on Molecular Medicine Conference Banner
The Cancer Story
World Congress on Advances in Oncology and International Symposium on Molecular Medicine Conference Banner
World Academy Of Sciences Banner
Heyday Road Banner

0

Copy and paste a formatted citation
x
Spandidos Publications style
Liu ZL, Wang C, Chen HJ, Li X, Dai LJ and Ding ZY: Bone metastasis from lung cancer identified by genetic profiling. Oncol Lett 13: 847-850, 2017.
APA
Liu, Z., Wang, C., Chen, H., Li, X., Dai, L., & Ding, Z. (2017). Bone metastasis from lung cancer identified by genetic profiling. Oncology Letters, 13, 847-850. https://doi.org/10.3892/ol.2016.5458
MLA
Liu, Z., Wang, C., Chen, H., Li, X., Dai, L., Ding, Z."Bone metastasis from lung cancer identified by genetic profiling". Oncology Letters 13.2 (2017): 847-850.
Chicago
Liu, Z., Wang, C., Chen, H., Li, X., Dai, L., Ding, Z."Bone metastasis from lung cancer identified by genetic profiling". Oncology Letters 13, no. 2 (2017): 847-850. https://doi.org/10.3892/ol.2016.5458