Apigenin enhances the cisplatin cytotoxic effect through p53‑modulated apoptosis

  • Authors:
    • Rui Liu
    • Ping Ji
    • Bin Liu
    • Haishi Qiao
    • Xia Wang
    • Likun Zhou
    • Ting Deng
    • Yi Ba
  • View Affiliations

  • Published online on: December 14, 2016     https://doi.org/10.3892/ol.2016.5495
  • Pages: 1024-1030
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Abstract

Epidemiological and experimental evidence suggests that dietary flavonoids, including apigenin, have anticancer roles. Apigenin has been reported to elevate p53, a critical molecule in the induction of apoptosis. The present study aimed to investigate whether apigenin, a dietary flavonoid, improves the cytotoxic effect of cisplatin in a cancer cell culture system, and to elucidate the mechanism of this effect. Multiple tumor cell types were treated with apigenin, cisplatin or both drugs. Cell viability was evaluated, and the cytotoxic effect was determined biochemically and microscopically. Treatment with apigenin increased cisplatin‑induced DNA damage and the apoptosis of tumor cells in a p53‑dependent manner. Apigenin, when used with cisplatin, inhibited cell proliferation and promoted mitogen‑activated protein kinase activation and subsequent p53 phosphorylation, leading to p53 accumulation and upregulation of proapoptotic proteins. Cisplatin is one of the most commonly used chemotherapeutic drugs for malignant tumors, but resistance to this drug occurs. The current results therefore demonstrate that dietary flavonoids may diminish the resistance of cancers to cisplatin.
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February-2017
Volume 13 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Liu R, Ji P, Liu B, Qiao H, Wang X, Zhou L, Deng T and Ba Y: Apigenin enhances the cisplatin cytotoxic effect through p53‑modulated apoptosis. Oncol Lett 13: 1024-1030, 2017.
APA
Liu, R., Ji, P., Liu, B., Qiao, H., Wang, X., Zhou, L. ... Ba, Y. (2017). Apigenin enhances the cisplatin cytotoxic effect through p53‑modulated apoptosis. Oncology Letters, 13, 1024-1030. https://doi.org/10.3892/ol.2016.5495
MLA
Liu, R., Ji, P., Liu, B., Qiao, H., Wang, X., Zhou, L., Deng, T., Ba, Y."Apigenin enhances the cisplatin cytotoxic effect through p53‑modulated apoptosis". Oncology Letters 13.2 (2017): 1024-1030.
Chicago
Liu, R., Ji, P., Liu, B., Qiao, H., Wang, X., Zhou, L., Deng, T., Ba, Y."Apigenin enhances the cisplatin cytotoxic effect through p53‑modulated apoptosis". Oncology Letters 13, no. 2 (2017): 1024-1030. https://doi.org/10.3892/ol.2016.5495