Prognostic significance of KLF4 expression in gastric cancer

  • Authors:
    • Isaya Hashimoto
    • Takuya Nagata
    • Shinichi Sekine
    • Makoto Moriyama
    • Kazuto Shibuya
    • Shozo Hojo
    • Koshi Matsui
    • Isaku Yoshioka
    • Tomoyuki Okumura
    • Takashi Hori
    • Yutaka Shimada
    • Kazuhiro Tsukada
  • View Affiliations

  • Published online on: December 14, 2016     https://doi.org/10.3892/ol.2016.5499
  • Pages: 819-826
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Abstract

To understand the roles of pluripotent stem cell‑inducing genes in gastric cancer, the expression of Krüppel‑like factor 4 (KLF4), Nanog, octamer‑binding transcription factor 4 (Oct4), avian myelocytomatosis viral oncogene homolog (c‑Myc) and sex‑determining region Y‑box 2 (SOX2) was examined using the newly developed gastric carcinoma tissue microarray. The associations between the immunohistochemical expression levels of the pluripotency‑inducing factors and the clinicopathological data of 108 patients with gastric cancer were analyzed. No associations were identified between the expression levels of the five pluripotency‑inducing factors and the tumor‑node‑metastasis (TNM) classification or clinicopathological characteristics of the patients. In addition, multivariate analysis revealed no association of Nanog, Oct4, SOX2 or c‑Myc with the prognosis of the gastric cancer patients; however, low expression of KLF4 was determined to be an independent negative prognostic factor (P=0.0331), particularly in patients who underwent R0 resection (TNM stages 2 and 3; P=0.0048). In summary, low KLF4 expression was found to be negatively associated with overall survival, and may therefore be a useful prognostic marker in gastric cancer patients.
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February-2017
Volume 13 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Hashimoto I, Nagata T, Sekine S, Moriyama M, Shibuya K, Hojo S, Matsui K, Yoshioka I, Okumura T, Hori T, Hori T, et al: Prognostic significance of KLF4 expression in gastric cancer. Oncol Lett 13: 819-826, 2017.
APA
Hashimoto, I., Nagata, T., Sekine, S., Moriyama, M., Shibuya, K., Hojo, S. ... Tsukada, K. (2017). Prognostic significance of KLF4 expression in gastric cancer. Oncology Letters, 13, 819-826. https://doi.org/10.3892/ol.2016.5499
MLA
Hashimoto, I., Nagata, T., Sekine, S., Moriyama, M., Shibuya, K., Hojo, S., Matsui, K., Yoshioka, I., Okumura, T., Hori, T., Shimada, Y., Tsukada, K."Prognostic significance of KLF4 expression in gastric cancer". Oncology Letters 13.2 (2017): 819-826.
Chicago
Hashimoto, I., Nagata, T., Sekine, S., Moriyama, M., Shibuya, K., Hojo, S., Matsui, K., Yoshioka, I., Okumura, T., Hori, T., Shimada, Y., Tsukada, K."Prognostic significance of KLF4 expression in gastric cancer". Oncology Letters 13, no. 2 (2017): 819-826. https://doi.org/10.3892/ol.2016.5499