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Primary bone mantle cell lymphomas with multiple vertebral compression fractures: A case report

  • Authors:
    • Peng Yang
    • Jun Lin
    • Hao Liu
    • Hao Shen
    • Hui‑Lin Yang

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  • Published online on: January 2, 2017     https://doi.org/10.3892/ol.2017.5553
  • Pages: 1288-1292
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

Mantle cell lymphoma (MCL) is a mature B‑cell non‑Hodgkin lymphoma. Patients with MCL generally present with extensive lymphadenopathy and extranodal involvement. To the best of our knowledge, no cases of primary bone MCL with multiple vertebral compression fractures have been reported in the literature thus far. The current study reports the case of a 75‑year‑old Chinese male patient presenting with lower back pain for 1 year. B symptoms were not observed in the patient's medical history. X‑ray revealed osteoporosis, and mixed osteolytic and osteosclerotic lesions in the T10 and L1 vertebrae with decreased height. Computed tomography of the spine showed multiple vertebral compression fractures, particularly at T10 and L1. Furthermore, magnetic resonance imaging demonstrated a diffuse homogeneous abnormal signal with multiple vertebral compression fractures. The patient underwent vertebral biopsy and percutaneous balloon kyphoplasty. Histopathological examination of the biopsy revealed abnormal, diffuse, atypical, small‑sized, slightly irregular lymphocytes with condensed chromatin. Immunohistochemical staining showed CD5+, CD20+ and cyclin D1+. Thus, the patient was diagnosed with primary bone MCLs and chemotherapy was administered. During the 2‑month follow‑up, the patient remained in a good clinical condition. The present study reports a rare case of primary osseous MCL and a review of the literature.
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March-2017
Volume 13 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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  • Impact Factor: 2.9
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  • CiteScore: 6.3
  • CiteScore Rank: Q2: #119/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.725
  • SCImago Journal Rank (SJR): 0.639
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Spandidos Publications style
Yang P, Lin J, Liu H, Shen H and Yang HL: Primary bone mantle cell lymphomas with multiple vertebral compression fractures: A case report. Oncol Lett 13: 1288-1292, 2017
APA
Yang, P., Lin, J., Liu, H., Shen, H., & Yang, H. (2017). Primary bone mantle cell lymphomas with multiple vertebral compression fractures: A case report. Oncology Letters, 13, 1288-1292. https://doi.org/10.3892/ol.2017.5553
MLA
Yang, P., Lin, J., Liu, H., Shen, H., Yang, H."Primary bone mantle cell lymphomas with multiple vertebral compression fractures: A case report". Oncology Letters 13.3 (2017): 1288-1292.
Chicago
Yang, P., Lin, J., Liu, H., Shen, H., Yang, H."Primary bone mantle cell lymphomas with multiple vertebral compression fractures: A case report". Oncology Letters 13, no. 3 (2017): 1288-1292. https://doi.org/10.3892/ol.2017.5553