Reciprocal regulation between microRNAs and epigenetic machinery in colorectal cancer (Review)

  • Authors:
    • Feng Wang
    • Yanlei Ma
    • Huamin Wang
    • Huanlong Qin
  • View Affiliations

  • Published online on: January 11, 2017     https://doi.org/10.3892/ol.2017.5593
  • Pages: 1048-1057
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Abstract

Epigenetics encompasses changes in DNA methylation, histone and chromatin structure, and non‑coding RNAs, specifically microRNA (miRNA) expression. Recent advances in the rapidly evolving field of colorectal cancer (CRC) epigenetics have revealed a complicated network of reciprocal interconnections between miRNAs and other epigenetic machinery. On the one hand, miRNA expression may be regulated by epigenetic mechanisms including DNA methylation and histone modifications. However, miRNAs may affect the epigenetic machinery by directly targeting its enzymatic components. In this study, we focus on the colorectal miRNA expression profile and further illustrate the reciprocal regulation in CRC, with the aim of offering new insights into the strategies of combatting the disease.
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March-2017
Volume 13 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Wang F, Ma Y, Wang H and Qin H: Reciprocal regulation between microRNAs and epigenetic machinery in colorectal cancer (Review). Oncol Lett 13: 1048-1057, 2017
APA
Wang, F., Ma, Y., Wang, H., & Qin, H. (2017). Reciprocal regulation between microRNAs and epigenetic machinery in colorectal cancer (Review). Oncology Letters, 13, 1048-1057. https://doi.org/10.3892/ol.2017.5593
MLA
Wang, F., Ma, Y., Wang, H., Qin, H."Reciprocal regulation between microRNAs and epigenetic machinery in colorectal cancer (Review)". Oncology Letters 13.3 (2017): 1048-1057.
Chicago
Wang, F., Ma, Y., Wang, H., Qin, H."Reciprocal regulation between microRNAs and epigenetic machinery in colorectal cancer (Review)". Oncology Letters 13, no. 3 (2017): 1048-1057. https://doi.org/10.3892/ol.2017.5593