Targeting of growth factors in the treatment of hepatocellular carcinoma: The potentials of polysaccharides (Review)
- Authors:
- Xuan Wang
- Jieyu Ding
- Yuanyuan Feng
- Lingling Weng
- Guangqiang Zhao
- Jianfeng Xiang
- Minguang Zhang
- Dongwei Xing
-
Affiliations: Radiology Department, Shanghai Municipal Hospital of Traditional Chinese Medicine Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200071, P.R. China, Oncology Department, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200021, P.R. China - Published online on: January 17, 2017 https://doi.org/10.3892/ol.2017.5602
- Pages: 1509-1517
This article is mentioned in:
Abstract
Jemal A, Siegel R, Xu J and Ward E: Cancer statistics, 2010. CA Cancer J Clin. 60:277–300. 2010. View Article : Google Scholar : PubMed/NCBI | |
AC Society, . Global cancer facts and figures. 2008.http://www.cancer.org/acs/groups/content/@editorial/documents/document/acspc-044552.pdfAccessed: December 16, 2016. | |
Lencioni R, Petruzzi P and Crocetti L: Chemoembolization of hepatocellular carcinoma. Semin Intervent Radiol. 30:3–11. 2013. View Article : Google Scholar : PubMed/NCBI | |
Kim HY and Park JW: Clinical trials of combined molecular targeted therapy and locoregional therapy in hepatocellular carcinoma: Past, present and future. Liver Cancer. 3:9–17. 2014. View Article : Google Scholar : PubMed/NCBI | |
Levin B and Amos C: Therapy of unresectable hepatocellular carcinoma. N Engl J Med. 332:1294–1296. 1995. View Article : Google Scholar : PubMed/NCBI | |
Nocentini G: Ribonucleotide reductase inhibitors: New strategies for cancer chemotherapy. Crit Rev Oncol Hematol. 22:89–126. 1996. View Article : Google Scholar : PubMed/NCBI | |
Deng C, Fu H, Teng L, Hu Z, Xu X, Chen J and Ren T: Anti-tumor activity of the regenerated triple-helical polysaccharide from Dictyophora indusiata. Int J Biol Macromol. 61:453–458. 2013. View Article : Google Scholar : PubMed/NCBI | |
Shen H, Tang G, Zeng G, Yang Y, Cai X, Li D, Liu H and Zhou N: Purification and characterization of an antitumor polysaccharide from Portulaca oleracea L. Carbohydr Polym. 93:395–400. 2013. View Article : Google Scholar : PubMed/NCBI | |
Yang Z, Xu J, Fu Q, Fu X, Shu T, Bi Y and Song B: Antitumor activity of a polysaccharide from Pleurotus eryngii on mice bearing renal cancer. Carbohydr Polym. 95:615–620. 2013. View Article : Google Scholar : PubMed/NCBI | |
Yang B, Xiao B and Sun T: Antitumor and immunomodulatory activity of Astragalus membranaceus polysaccharides in H22 tumor-bearing mice. Int J Biol Macromol. 62:287–290. 2013. View Article : Google Scholar : PubMed/NCBI | |
Odenthal J, Takes R and Friedl P: Plasticity of tumor cell invasion: Governance by growth factors and cytokines. Carcinogenesis. 37:1117–1128. 2016.PubMed/NCBI | |
Hanahan D and Weinberg RA: The hallmarks of cancer. Cell. 100:57–70. 2000. View Article : Google Scholar : PubMed/NCBI | |
Hanada K, Perry-Lalley DM, Ohnmacht GA, Bettinotti MP and Yang JC: Identification of fibroblast growth factor-5 as an overexpressed antigen in multiple human adenocarcinomas. Cancer Res. 61:5511–5516. 2001.PubMed/NCBI | |
Habib SA, Aggour YA and Taha HA: Downregulation of transforming growth factor- β (TGF-) and vascular endothelial growth factor (VEGF) in ehrlich ascites carcinoma-bearing mice using stearic acid-grafted carboxymethyl chitosan (SA-CMC). Nat Sci. 4:808–818. 2012. | |
Wolf HK, Zarnegar R and Michalopoulos GK: Localization of hepatocyte growth factor in human and rat tissues: An immunohistochemical study. Hepatology. 14:488–494. 1991. View Article : Google Scholar : PubMed/NCBI | |
Awuah PK, Nejak-Bowen KN and Monga SP: Role and regulation of PDGFRα signaling in liver development and regeneration. Am J Pathol. 182:1648–1658. 2013. View Article : Google Scholar : PubMed/NCBI | |
Suzuki A, Iwama A, Miyashita H, Nakauchi H and Taniguchi H: Role for growth factors and extracellular matrix in controlling differentiation of prospectively isolated hepatic stem cells. Development. 130:2513–2524. 2003. View Article : Google Scholar : PubMed/NCBI | |
Duncan SA: Mechanisms controlling early development of the liver. Mech Dev. 120:19–33. 2003. View Article : Google Scholar : PubMed/NCBI | |
Breuhahn K, Longerich T and Schirmacher P: Dysregulation of growth factor signaling in human hepatocellular carcinoma. Oncogene. 25:3787–3800. 2006. View Article : Google Scholar : PubMed/NCBI | |
Shibuya M: Vascular endothelial growth factor and its receptor system: Physiological functions in angiogenesis and pathological roles in various diseases. J Biochem. 153:13–39. 2013. View Article : Google Scholar : PubMed/NCBI | |
Shibuya M and Claesson-Welsh L: Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis. Exp Cell Res. 312:549–560. 2006. View Article : Google Scholar : PubMed/NCBI | |
Bhardwaj S, Roy H, Babu M, Shibuya M and Yla-Herttuala S: Adventitial gene transfer of VEGFR-2 specific VEGF-E chimera induces MCP-1 expression in vascular smooth muscle cells and enhances neointimal formation. Atherosclerosis. 219:84–91. 2011. View Article : Google Scholar : PubMed/NCBI | |
Meyer JP, Edwards KJ, Kozlowski P, Backer MV, Backer JM and Lewis JS: Selective imaging of VEGFR-1 and VEGFR-2 using 89Zr-labeled single-chain VEGF mutants. J Nucl Med. 57:1811–1816. 2016. View Article : Google Scholar : PubMed/NCBI | |
Kanematsu M, Semelka RC, Osada S and Amaoka N: Magnetic resonance imaging and expression of vascular endothelial growth factor in hepatocellular nodules in cirrhosis and hepatocellular carcinomas. Top Magn Reson Imaging. 16:67–75. 2005. View Article : Google Scholar : PubMed/NCBI | |
Schoenleber SJ, Kurtz DM, Talwalkar JA, Roberts LR and Gores GJ: Prognostic role of vascular endothelial growth factor in hepatocellular carcinoma: Systematic review and meta-analysis. Br J Cancer. 100:1385–1392. 2009. View Article : Google Scholar : PubMed/NCBI | |
Raskopf E, Dzienisowicz C, Hilbert T, Rabe C, Leifeld L, Wernert N, Sauerbruch T, Prieto J, Qian C, Caselmann WH and Schmitz V: Effective angiostatic treatment in a murine metastatic and orthotopic hepatoma model. Hepatology. 41:1233–1240. 2005. View Article : Google Scholar : PubMed/NCBI | |
Tan HY, Wang N, Tsao SW, Zhang Z and Feng Y: Suppression of vascular endothelial growth factor via inactivation of eukaryotic elongation factor 2 by alkaloids in Coptidis rhizoma in hepatocellular carcinoma. Integr Cancer Ther. 13:425–434. 2014. View Article : Google Scholar : PubMed/NCBI | |
Gao JZ, Du JL, Wang YL, Li J, Wei LX and Guo MZ: Synergistic effects of curcumin and bevacizumab on cell signaling pathways in hepatocellular carcinoma. Oncol Lett. 9:295–299. 2015.PubMed/NCBI | |
Hoshida Y, Nijman SM, Kobayashi M, Chan JA, Brunet JP, Chiang DY, Villanueva A, Newell P, Ikeda K, Hashimoto M, et al: Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma. Cancer Res. 69:7385–7392. 2009. View Article : Google Scholar : PubMed/NCBI | |
Ru NY, Wu J, Chen ZN and Bian H: HAb18G/CD147 is involved in TGF-β-induced epithelial-mesenchymal transition and hepatocellular carcinoma invasion. Cell Biol Int. 39:44–51. 2015. View Article : Google Scholar : PubMed/NCBI | |
Yu W, Huang C, Wang Q, Huang T, Ding Y, Ma C, Ma H and Chen W: MEF2 transcription factors promotes EMT and invasiveness of hepatocellular carcinoma through TGF-β1 autoregulation circuitry. Tumour Biol. 35:10943–10951. 2014. View Article : Google Scholar : PubMed/NCBI | |
Buckley AF, Burgart LJ, Sahai V and Kakar S: Epidermal growth factor receptor expression and gene copy number in conventional hepatocellular carcinoma. Am J Clin Pathol. 129:245–251. 2008. View Article : Google Scholar : PubMed/NCBI | |
Lai JP, Chien JR, Moser DR, Staub JK, Aderca I, Montoya DP, Matthews TA, Nagorney DM, Cunningham JM, Smith DI, et al: hSulf1 Sulfatase promotes apoptosis of hepatocellular cancer cells by decreasing heparin-binding growth factor signaling. Gastroenterology. 126:231–248. 2004. View Article : Google Scholar : PubMed/NCBI | |
Höpfner M, Schuppan D and Scherübl H: Growth factor receptors and related signalling pathways as targets for novel treatment strategies of hepatocellular cancer. World J Gastroenterol. 14:1–14. 2008. View Article : Google Scholar : PubMed/NCBI | |
35. Wilhelm SM, Adnane L, Newell P, Villanueva A, Llovet JM and Lynch M: Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling. Mol Cancer Ther. 7:3129–3140. 2008. View Article : Google Scholar : PubMed/NCBI | |
Sprinzl MF, Puschnik A, Schlitter AM, Schad A, Ackermann K, Esposito I, Lang H, Galle PR, Weinmann A, Heikenwälder M and Protzer U: Sorafenib inhibits macrophage-induced growth of hepatoma cells by interference with insulin-like growth factor-1 secretion. J Hepatol. 62:863–870. 2015. View Article : Google Scholar : PubMed/NCBI | |
Albert DH, Tapang P, Magoc TJ, Pease LJ, Reuter DR, Wei RQ, Li J, Guo J, Bousquet PF, Ghoreishi-Haack NS, et al: Preclinical activity of ABT-869, a multitargeted receptor tyrosine kinase inhibitor. Mol Cancer Ther. 5:995–1006. 2006. View Article : Google Scholar : PubMed/NCBI | |
Blivet-Van Eggelpoël MJ, Chettouh H, Fartoux L, Aoudjehane L, Barbu V, Rey C, Priam S, Housset C, Rosmorduc O and Desbois-Mouthon C: Epidermal growth factor receptor and HER-3 restrict cell response to sorafenib in hepatocellular carcinoma cells. J Hepatol. 57:108–115. 2012. View Article : Google Scholar : PubMed/NCBI | |
Zhai B and Sun XY: Mechanisms of resistance to sorafenib and the corresponding strategies in hepatocellular carcinoma. World J Hepatol. 5:345–352. 2013. View Article : Google Scholar : PubMed/NCBI | |
Bruix J and Sherman M: American Association for the Study of Liver Diseases: Management of hepatocellular carcinoma: An update. Hepatology. 53:1020–1022. 2011. View Article : Google Scholar : PubMed/NCBI | |
Cheng AL, Kang YK, Chen Z, Tsao CJ, Qin S, Kim JS, Luo R, Feng J, Ye S, Yang TS, et al: Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: A phase III randomised, double-blind, placebo-controlled trial. Lancet Oncol. 10:25–34. 2009. View Article : Google Scholar : PubMed/NCBI | |
Ali BH, Ziada A and Blunden G: Biological effects of gum arabic: A review of some recent research. Food Chem Toxicol. 47:1–8. 2009. View Article : Google Scholar : PubMed/NCBI | |
Yu Z, LiHua Y, Qian Y and Yan L: Effect of Lentinus edodes polysaccharide on oxidative stress, immunity activity and oral ulceration of rats stimulated by phenol. Carbohydrate Polymers. 75:115–118. 2009. View Article : Google Scholar | |
Zong A, Cao H and Wang F: Anticancer polysaccharides from natural resources: A review of recent research. Carbohydr Polym. 90:1395–1410. 2012. View Article : Google Scholar : PubMed/NCBI | |
Ajith TA and Janardhanan KK: Cytotoxic and antitumor activities of a polypore macrofungus, Phellinus rimosus (Berk) Pilat. J Ethnopharmacol. 84:157–162. 2003. View Article : Google Scholar : PubMed/NCBI | |
Santos-Neves JC, Pereira MI, Carbonero ER, Gracher AHP, Alquini G, Gorin PAJ, Sassaki GL and Iacomini M: A novel branched αβ-glucan isolated from the basidiocarps of the edible mushroom Pleurotus florida. Carbohydrate Polymers. 73:309–314. 2008. View Article : Google Scholar | |
Wong SM, Wong KK, Chiu LCM and Cheung PCK: Non-starch polysaccharides from different developmental stages of Pleurotus tuber-regium inhibited the growth of human acute promyelocytic leukemia HL-60 cells by cell-cycle arrest and/or apoptotic induction. Carbohydrate Polymers. 68:206–217. 2007. View Article : Google Scholar | |
Zhang M, Cheung PCK, Chiu LCM, Wong EYL and Ooi VEC: Cell-cycle arrest and apoptosis induction in human breast carcinoma MCF-7 cells by carboxymethylated β-glucan from the mushroom sclerotia of Pleurotus tuber-regium. Carbohydrate Polymers. 66:455–462. 2006. View Article : Google Scholar | |
Lavi I, Nimri L, Levinson D, Peri I, Hadar Y and Schwartz B: Glucans from the edible mushroom Pleurotus pulmonarius inhibit colitis-associated colon carcinogenesis in mice. J Gastroenterol. 47:504–518. 2012. View Article : Google Scholar : PubMed/NCBI | |
Maehara Y, Tsujitani S, Saeki H, Oki E, Yoshinaga K, Emi Y, Morita M, Kohnoe S, Kakeji Y, Yano T, et al: Biological mechanism and clinical effect of protein-bound polysaccharide K (KRESTIN(®)): Review of development and future perspectives. Surg Today. 42:8–28. 2012. View Article : Google Scholar : PubMed/NCBI | |
Zeng Q, Zhou F, Lei L, Chen J, Lu J, Zhou J, Cao K, Gao L, Xia F, Ding S, et al: Ganoderma lucidum polysaccharides protect fibroblasts against UVB-induced photoaging. Mol Med Rep. 2016. | |
Hu X, Zhang R, Xie Y, Wang H and Ge M: The protective effects of polysaccharides from Agaricus blazei Murill against cadmium-induced oxidant stress and inflammatory damage in chicken livers. Biol Trace Elem Res. 2016. View Article : Google Scholar | |
Li S, Gao A, Dong S, Chen Y, Sun S, Lei Z and Zhang Z: Purification, antitumor and immunomodulatory activity of polysaccharides from soybean residue fermented with Morchella esculenta. Int J Biol Macromo. 96:26–34. 2016. View Article : Google Scholar | |
Lv Y, Yang X, Zhao Y, Ruan Y, Yang Y and Wang Z: Separation and quantification of component monosaccharides of the tea polysaccharides from Gynostemma pentaphyllum by HPLC with indirect UV detection. Food Chemistry. 112:742–746. 2009. View Article : Google Scholar | |
Lu X, Zhao Y, Sun Y, Yang S and Yang X: Characterisation of polysaccharides from green tea of Huangshan Maofeng with antioxidant and hepatoprotective effects. Food Chem. 141:3415–3423. 2013. View Article : Google Scholar : PubMed/NCBI | |
Yang X, Zhao Y, Yang Y and Ruan Y: Isolation and characterization of immunostimulatory polysaccharide from an herb tea, Gynostemma pentaphyllum Makino. J Agric Food Chem. 56:6905–6909. 2008. View Article : Google Scholar : PubMed/NCBI | |
Chen J, Yong Y, Xing M, Gu Y, Zhang Z, Zhang S and Lu L: Characterization of polysaccharides with marked inhibitory effect on lipid accumulation in Pleurotus eryngii. Carbohydr Polym. 97:604–613. 2013. View Article : Google Scholar : PubMed/NCBI | |
Zhang Y, Dai L, Kong X and Chen L: Characterization and in vitro antioxidant activities of polysaccharides from Pleurotus ostreatus. Int J Biol Macromol. 51:259–265. 2012. View Article : Google Scholar : PubMed/NCBI | |
Li X, Zhang H and Xu H: Analysis of chemical components of shiitake polysaccharides and its anti-fatigue effect under vibration. Int J Biol Macromol. 45:377–380. 2009. View Article : Google Scholar : PubMed/NCBI | |
Wang M, Wang H, Tang Y, Kang D, Gao Y, Ke M, Dou J, Xi T and Zhou C: Effective inhibition of a Strongylocentrotus nudus eggs polysaccharide against hepatocellular carcinoma is mediated via immunoregulation in vivo. Immunol Lett. 141:74–82. 2011. View Article : Google Scholar : PubMed/NCBI | |
Zhang CX and Huang KX: Mechanism of apoptosis induced by a polysaccharide, from the loach Misgurnus anguillicaudatus (MAP) in human hepatocellular carcinoma cells. Toxicol Appl Pharmacol. 210:236–245. 2006. View Article : Google Scholar : PubMed/NCBI | |
Isoda N, Eguchi Y, Nukaya H, Hosho K, Suga Y, Suga T, Nakazawa S and Sugano K: Clinical efficacy of superfine dispersed lentinan (β-1,3-glucan) in patients with hepatocellular carcinoma. Hepatogastroenterology. 56:437–441. 2009.PubMed/NCBI | |
Ruan WJ, Lai MD and Zhou JG: Anticancer effects of Chinese herbal medicine, science or myth? J Zhejiang Univ Sci B. 7:1006–1014. 2006. View Article : Google Scholar : PubMed/NCBI | |
Konkimalla VB and Efferth T: Evidence-based Chinese medicine for cancer therapy. J Ethnopharmacol. 116:207–210. 2008. View Article : Google Scholar : PubMed/NCBI | |
Niwa Y, Matsuura H, Murakami M, Sato J, Hirai K and Sumi H: Evidence that naturopathic therapy including Cordyceps sinensis prolongs survival of patients with hepatocellular carcinoma. Integr Cancer Ther. 12:50–68. 2013. View Article : Google Scholar : PubMed/NCBI | |
Wang CR, Ng TB, Li L, Fang JC, Jiang Y, Wen TY, Qiao WT, Li N and Liu F: Isolation of a polysaccharide with antiproliferative, hypoglycemic, antioxidant and HIV-1 reverse transcriptase inhibitory activities from the fruiting bodies of the abalone mushroom Pleurotus abalonus. J Pharm Pharmacol. 63:825–832. 2011. View Article : Google Scholar : PubMed/NCBI | |
Xu WW, Li B, Lai ET, Chen L, Huang JJ, Cheung AL and Cheung PC: Water extract from Pleurotus pulmonarius with antioxidant activity exerts in vivo chemoprophylaxis and chemosensitization for liver cancer. Nutr Cancer. 66:989–998. 2014. View Article : Google Scholar : PubMed/NCBI | |
Xu W, Huang JJ and Cheung PC: Extract of Pleurotus pulmonarius suppresses liver cancer development and progression through inhibition of VEGF-induced PI3K/AKT signaling pathway. PLoS One. 7:e344062012. View Article : Google Scholar : PubMed/NCBI | |
Xu R, Ye H, Sun Y, Tu Y and Zeng X: Preparation, preliminary characterization, antioxidant, hepatoprotective and antitumor activities of polysaccharides from the flower of tea plant (Camellia sinensis). Food Chem Toxicol. 50:2473–2480. 2012. View Article : Google Scholar : PubMed/NCBI | |
Chen B, Zhou W, Ning M, Wang Z, Zou L, Zhang H and Wang Q: Evaluation of antitumour activity of tea carbohydrate polymers in hepatocellular carcinoma animals. Int J Biol Macromol. 50:1103–1108. 2012. View Article : Google Scholar : PubMed/NCBI | |
Liang G, Tang A, Lin X, Li L, Zhang S, Huang Z, Tang H and Li QQ: Green tea catechins augment the antitumor activity of doxorubicin in an in vivo mouse model for chemoresistant liver cancer. Int J Oncol. 37:111–123. 2010.PubMed/NCBI | |
He X, Li X, Liu B, Xu L, Zhao H and Lu A: Down-regulation of Treg cells and up-regulation of TH1/TH2 cytokine ratio were induced by polysaccharide from Radix Glycyrrhizae in H22 hepatocarcinoma bearing mice. Molecules. 16:8343–8352. 2011. View Article : Google Scholar : PubMed/NCBI | |
Wu S, Liu B, Zhang Q, Liu J, Zhou W, Wang C, Li M, Bao S and Zhu R: Dihydromyricetin reduced Bcl-2 expression via p53 in human hepatoma HepG2 cells. PLoS One. 8:e768862013. View Article : Google Scholar : PubMed/NCBI | |
Liu J, Shu Y, Zhang Q, Liu B, Xia J, Qiu M, Miao H, Li M and Zhu R: Dihydromyricetin induces apoptosis and inhibits proliferation in hepatocellular carcinoma cells. Oncol Lett. 8:1645–1651. 2014.PubMed/NCBI | |
Zhang Q, Liu J, Liu B, Xia J, Chen N, Chen X, Cao Y, Zhang C, Lu C, Li M and Zhu R: Dihydromyricetin promotes hepatocellular carcinoma regression via a p53 activation-dependent mechanism. Sci Rep. 4:46282014.PubMed/NCBI | |
Jiang L, Zhang Q, Ren H, Ma S, Lu C, Liu B, Liu J, Liang J, Li M and Zhu R: Dihydromyricetin enhances the chemo-sensitivity of nedaplatin via regulation of the p53/Bcl-2 pathway in hepatocellular carcinoma cells. PLoS One. 10:e01249942015. View Article : Google Scholar : PubMed/NCBI | |
Liu B, Zhou W, Chen X, Xu F, Chen Y, Liu J, Zhang Q, Bao S, Chen N, Li M and Zhu R: Dihydromyricetin induces mouse hepatoma Hepal-6 cell apoptosis via the transforming growth factor-β pathway. Mol Med Rep. 11:1609–1614. 2015.PubMed/NCBI | |
Lever R and Page C: Novel drug development opportunities for heparin. Nat Rev Drug Discov. 1:140–148. 2002. View Article : Google Scholar : PubMed/NCBI | |
Presta M, Leali D, Stabile H, Ronca R, Camozzi M, Coco L, Moroni E, Liekens S and Rusnati M: Heparin derivatives as angiogenesis inhibitors. Curr Pharm Des. 9:553–566. 2003. View Article : Google Scholar : PubMed/NCBI | |
Ferro V, Dredge K, Liu L, Hammond E, Bytheway I, Li C, Johnstone K, Karoli T, Davis K, Copeman E and Gautam A: PI-88 and novel heparan sulfate mimetics inhibit angiogenesis. Semin Thromb Hemost. 33:557–568. 2007. View Article : Google Scholar : PubMed/NCBI | |
Dredge K, Hammond E, Davis K, Li CP, Liu L, Johnstone K, Handley P, Wimmer N, Gonda TJ, Gautam A, et al: The PG500 series: Novel heparan sulfate mimetics as potent angiogenesis and heparanase inhibitors for cancer therapy. Invest New Drugs. 28:276–283. 2010. View Article : Google Scholar : PubMed/NCBI | |
Budhu A and Wang XW: The role of cytokines in hepatocellular carcinoma. J Leukoc Biol. 80:1197–1213. 2006. View Article : Google Scholar : PubMed/NCBI | |
Nakamoto Y, Guidotti LG, Kuhlen CV, Fowler P and Chisari FV: Immune pathogenesis of hepatocellular carcinoma. J Exp Med. 188:341–350. 1998. View Article : Google Scholar : PubMed/NCBI | |
Chuma M, Hige S, Nakanishi M, Ogawa K, Natsuizaka M, Yamamoto Y and Asaka M: 8-Hydroxy-2′-deoxy-guanosine is a risk factor for development of hepatocellular carcinoma in patients with chronic hepatitis C virus infection. J Gastroenterol Hepatol. 23:1431–1436. 2008. View Article : Google Scholar : PubMed/NCBI | |
Tanaka H, Fujita N, Sugimoto R, Urawa N, Horiike S, Kobayashi Y, Iwasa M, Ma N, Kawanishi S, Watanabe S, et al: Hepatic oxidative DNA damage is associated with increased risk for hepatocellular carcinoma in chronic hepatitis C. Br J Cancer. 98:580–586. 2008. View Article : Google Scholar : PubMed/NCBI | |
Marra M, Sordelli IM, Lombardi A, Lamberti M, Tarantino L, Giudice A, Stiuso P, Abbruzzese A, Sperlongano R, Accardo M, et al: Molecular targets and oxidative stress biomarkers in hepatocellular carcinoma: An overview. J Transl Med. 9:1712011. View Article : Google Scholar : PubMed/NCBI | |
Bishayee A: The role of inflammation and liver cancer. Adv Exp Med Biol. 816:401–435. 2014. View Article : Google Scholar : PubMed/NCBI | |
Klampfer L: Cytokines, inflammation and colon cancer. Curr Cancer Drug Targets. 11:451–464. 2011. View Article : Google Scholar : PubMed/NCBI | |
Chang HL, Lei LS, Yu CL, Zhu ZG, Chen NN and Wu SG: Effect of Flammulina velutipes polysaccharides on production of cytokines by murine immunocytes and serum levels of cytokines in tumor-bearing mice. Zhong Yao Cai. 32:561–563. 2009.(In Chinese). PubMed/NCBI | |
Chen G, Xu J, Miao X, Huan Y, Liu X, Ju Y and Han X: Characterization and antitumor activities of the water-soluble polysaccharide from Rhizoma Arisaematis. Carbohydr Polym. 90:67–72. 2012. View Article : Google Scholar : PubMed/NCBI | |
Wang LJ, Bai L, Su D, Zhang T and Mao ZY: Proinflammatory conditions promote hepatocellular carcinoma onset and progression via activation of Wnt and EGFR signaling pathways. Mol Cell Biochem. 381:173–181. 2013. View Article : Google Scholar : PubMed/NCBI | |
Cassetta L, Cassol E and Poli G: Macrophage polarization in health and disease. ScientificWorldJournal. 11:2391–2402. 2011. View Article : Google Scholar : PubMed/NCBI | |
Yang J, Li X, Xue Y, Wang N and Liu W: Anti-hepatoma activity and mechanism of corn silk polysaccharides in H22 tumor-bearing mice. Int J Biol Macromol. 64:276–280. 2014. View Article : Google Scholar : PubMed/NCBI | |
Liu L, Jia J, Zeng G, Zhao Y, Qi X, He C, Guo W, Fan D, Han G and Li Z: Studies on immunoregulatory and anti-tumor activities of a polysaccharide from Salvia miltiorrhiza Bunge. Carbohydr Polym. 92:479–483. 2013. View Article : Google Scholar : PubMed/NCBI | |
Tian QE, Li HD, Yan M, Cai HL, Tan QY and Zhang WY: Astragalus polysaccharides can regulate cytokine and P-glycoprotein expression in H22 tumor-bearing mice. World J Gastroenterol. 18:7079–7086. 2012. View Article : Google Scholar : PubMed/NCBI | |
Schild L, Chen BH, Makarov P, Kattengell K, Heinitz K and Keilhoff G: Selective induction of apoptosis in glioma tumour cells by a Gynostemma pentaphyllum extract. Phytomedicine. 17:589–597. 2010. View Article : Google Scholar : PubMed/NCBI | |
Chen J, Chen J, Wang X and Liu C: Anti-tumour effects of polysaccharides isolated from Artemisia annua L by inducing cell apoptosis and immunomodulatory anti-hepatoma effects of polysaccharides. Afr J Tradit Complement Altern Med. 11:15–22. 2013.PubMed/NCBI | |
Liang M, Li S, Shen B, Cai JP, Li C, Wang ZY, Li XG, Gao J, Huang HY, Zhang XY and Li JY: Anti-hepatocarcinoma effects of Aconitum coreanum polysaccharides. Carbohydrate Polymers. 88:973–976. 2012. View Article : Google Scholar | |
Zhang W, Li J, Qiu S, Chen J and Zheng Y: Effects of the exopolysaccharide fraction (EPSF) from a cultivated Cordyceps sinensis on immunocytes of H22 tumor bearing mice. Fitoterapia. 79:168–173. 2008. View Article : Google Scholar : PubMed/NCBI | |
Byeon SE, Lee J, Lee E, Lee SY, Hong EK, Kim YE and Cho JY: Functional activation of macrophages, monocytes and splenic lymphocytes by polysaccharide fraction from Tricholoma matsutake. Arch Pharm Res. 32:1565–1572. 2009. View Article : Google Scholar : PubMed/NCBI | |
Kim JY, Byeon SE, Lee YG, Lee JY, Park J, Hong EK and Cho JY: Immunostimulatory activities of polysaccharides from liquid culture of pine-mushroom Tricholoma matsutake. J Microbiol Biotechnol. 18:95–103. 2008.PubMed/NCBI | |
Ren M, Ye L, Hao X, Ren Z, Ren S, Xu K and Li J: Polysaccharides from Tricholoma matsutake and Lentinus edodes enhance 5-fluorouracil-mediated H22 cell growth inhibition. J Tradit Chin Med. 34:309–316. 2014. View Article : Google Scholar : PubMed/NCBI | |
Kim DH and Rossi JJ: Strategies for silencing human disease using RNA interference. Nat Rev Genet. 8:173–184. 2007. View Article : Google Scholar : PubMed/NCBI | |
Takeshita F and Ochiya T: Therapeutic potential of RNA interference against cancer. Cancer Sci. 97:689–696. 2006. View Article : Google Scholar : PubMed/NCBI | |
Whitehead KA, Langer R and Anderson DG: Knocking down barriers: Advances in siRNA delivery. Nat Rev Drug Discov. 8:129–138. 2009. View Article : Google Scholar : PubMed/NCBI | |
Huang Z, Dong L, Chen J, Gao F, Zhang Z, Chen J and Zhang J: Low-molecular weight chitosan/vascular endothelial growth factor short hairpin RNA for the treatment of hepatocellular carcinoma. Life Sci. 91:1207–1215. 2012. View Article : Google Scholar : PubMed/NCBI | |
Xu Y, Wen Z and Xu Z: Chitosan nanoparticles inhibit the growth of human hepatocellular carcinoma xenografts through an antiangiogenic mechanism. Anticancer Res. 29:5103–5109. 2009.PubMed/NCBI | |
Han L, Tang C and Yin C: Oral delivery of shRNA and siRNA via multifunctional polymeric nanoparticles for synergistic cancer therapy. Biomaterials. 35:4589–4600. 2014. View Article : Google Scholar : PubMed/NCBI | |
Roy M, Luo YH, Ye M and Liu J: Nonsmall cell lung cancer therapy: Insight into multitargeted small-molecule growth factor receptor inhibitors. Biomed Res Int. 2013:9647432013. View Article : Google Scholar : PubMed/NCBI | |
Wang E, Chen X, Wang K, Wang J, Chen D, Geng Y, Lai W and Wei X: Plant polysaccharides used as immunostimulants enhance innate immune response and disease resistance against Aeromonas hydrophila infection in fish. Fish Shellfish Immunol. 59:196–202. 2016. View Article : Google Scholar : PubMed/NCBI |