TRIM24 promotes the aggression of gastric cancer via the Wnt/β‑catenin signaling pathway

  • Authors:
    • Ziling Fang
    • Jun Deng
    • Ling Zhang
    • Xiaojun Xiang
    • Feng Yu
    • Jun Chen
    • Miao Feng
    • Jianping Xiong
  • View Affiliations

  • Published online on: January 17, 2017     https://doi.org/10.3892/ol.2017.5604
  • Pages: 1797-1806
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Abstract

Tripartite motif-containing 24 (TRIM24) is important in tumor development and progression. However, the role of TRIM24 in gastric cancer (GC) and the mechanisms underlying the dysregulated expression of TRIM24 remain to be fully elucidated. In the present study, it was found that TRIM24 was frequently overexpressed in GC cell lines and tissues compared with normal controls, as determined by western blotting and immunohistochemical staining. The high nuclear expression of TRIM24 was correlated with the depth of invasion (P=0.007), tumor‑node‑metastasis stage (P=0.005), and lymph node metastasis (P=0.027), and shorter overall survival rates (P=0.010) in patients with GC. Small interfering RNA‑mediated knockdown of TRIM24 inhibited cell proliferation, colony formation, migration, invasion and the nuclear accumulation of β‑catenin, and it delayed cell cycle progression and induced apoptosis. In addition, the expression of TRIM24 was positively correlated with that of β‑catenin in GC tissues. TRIM24 knockdown decreased the expression of Wnt/β‑catenin target genes, whereas the activation of Wnt/β‑catenin signaling by lithium chloride reversed the effects of TRIM24 knockdown. Taken together, these data suggested that TRIM24 was a prognostic or potential therapeutic target for patients with GC and was important in the activation of the Wnt/β‑catenin pathway during the progression of GC.
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March-2017
Volume 13 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Fang Z, Deng J, Zhang L, Xiang X, Yu F, Chen J, Feng M and Xiong J: TRIM24 promotes the aggression of gastric cancer via the Wnt/β‑catenin signaling pathway. Oncol Lett 13: 1797-1806, 2017
APA
Fang, Z., Deng, J., Zhang, L., Xiang, X., Yu, F., Chen, J. ... Xiong, J. (2017). TRIM24 promotes the aggression of gastric cancer via the Wnt/β‑catenin signaling pathway. Oncology Letters, 13, 1797-1806. https://doi.org/10.3892/ol.2017.5604
MLA
Fang, Z., Deng, J., Zhang, L., Xiang, X., Yu, F., Chen, J., Feng, M., Xiong, J."TRIM24 promotes the aggression of gastric cancer via the Wnt/β‑catenin signaling pathway". Oncology Letters 13.3 (2017): 1797-1806.
Chicago
Fang, Z., Deng, J., Zhang, L., Xiang, X., Yu, F., Chen, J., Feng, M., Xiong, J."TRIM24 promotes the aggression of gastric cancer via the Wnt/β‑catenin signaling pathway". Oncology Letters 13, no. 3 (2017): 1797-1806. https://doi.org/10.3892/ol.2017.5604