Neutrophil‑lymphocyte ratio predicts survival in pancreatic neuroendocrine tumors

  • Authors:
    • Guopei Luo
    • Chen Liu
    • He Cheng
    • Kaizhou Jin
    • Meng Guo
    • Yu Lu
    • Jiang Long
    • Jin Xu
    • Quanxing Ni
    • Jie Chen
    • Xianjun Yu
  • View Affiliations

  • Published online on: February 13, 2017     https://doi.org/10.3892/ol.2017.5716
  • Pages: 2454-2458
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Abstract

Although the prognostic role of neutrophil‑lympho­cyte ratio (NLR) has been confirmed in a variety of tumors, the prognostic role of NLR in pancreatic neuroendocrine tumors (PNETs) has not been examined. The present study was performed to assess the role of NLR as a prognostic factor in patients with PNETs. Clinical data were retrospectively retrieved from a single institution. The best cut‑off value for baseline NLR levels was determined by the receiver operating characteristic (ROC) curve and area under the ROC curve. The primary event was overall survival and event times were assessed by the Kaplan‑Meier method. Potential factors associated with the elevation of NLR in PNETs were examined. A total of 165 consecutive patients with pathologically confirmed PNETs were included in this study. The cutoff value of NLR was 2.4 by ROC curve (area under ROC curve, 0.70). NLR >2.4 was found to be a poor prognostic factor in the univariate and multivariate analyses. Patients with a NLR value >2.4 had a higher proportion of tumor size at >3 cm (P=0.001), TNM stage III or IV (P=0.019), and G2/G3 (P=0.003). We concluded that NLR is an independent predictor of overall survival for patients with PNETs. Aberrant elevation of NLR identifies high‑risk patients with aggressive characteristics.

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April-2017
Volume 13 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Luo G, Liu C, Cheng H, Jin K, Guo M, Lu Y, Long J, Xu J, Ni Q, Chen J, Chen J, et al: Neutrophil‑lymphocyte ratio predicts survival in pancreatic neuroendocrine tumors. Oncol Lett 13: 2454-2458, 2017
APA
Luo, G., Liu, C., Cheng, H., Jin, K., Guo, M., Lu, Y. ... Yu, X. (2017). Neutrophil‑lymphocyte ratio predicts survival in pancreatic neuroendocrine tumors. Oncology Letters, 13, 2454-2458. https://doi.org/10.3892/ol.2017.5716
MLA
Luo, G., Liu, C., Cheng, H., Jin, K., Guo, M., Lu, Y., Long, J., Xu, J., Ni, Q., Chen, J., Yu, X."Neutrophil‑lymphocyte ratio predicts survival in pancreatic neuroendocrine tumors". Oncology Letters 13.4 (2017): 2454-2458.
Chicago
Luo, G., Liu, C., Cheng, H., Jin, K., Guo, M., Lu, Y., Long, J., Xu, J., Ni, Q., Chen, J., Yu, X."Neutrophil‑lymphocyte ratio predicts survival in pancreatic neuroendocrine tumors". Oncology Letters 13, no. 4 (2017): 2454-2458. https://doi.org/10.3892/ol.2017.5716