Epigenetic silencing of protocadherin 10 in colorectal cancer (Review)

  • Authors:
    • Xian Zhong
    • Hong Shen
    • Jianshan Mao
    • Jiawei Zhang
    • Weidong Han
  • View Affiliations

  • Published online on: February 13, 2017     https://doi.org/10.3892/ol.2017.5733
  • Pages: 2449-2453
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Abstract

Colorectal cancer (CRC) is one of the most common types of malignant tumor in the world and occurs through a multi-step process resulting from the accumulation of genetic and epigenetic alterations of the genome. Although the molecular mechanisms of the pathogenesis of CRC remain unclear, the inactivation of tumor suppressor genes (TSGs) through promoter methylation serves an important role. Aberrant methylation is a well‑defined marker of CRC. At present, the epigenetic silencing of protocadherin 10 (PCDH10) has been identified as an important TSG with key roles in colorectal carcinogenesis, invasion and metastasis as a frequent and early event. Advances in gene methylation detection in tumor tissues and body fluids have led to the development of non‑invasive screening methods for CRC. The present study aimed to review the epigenetic alteration of PCDH10 in CRC development, and the potential of PCDH10 to be a non-invasive biomarker for CRC.

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April-2017
Volume 13 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Zhong X, Shen H, Mao J, Zhang J and Han W: Epigenetic silencing of protocadherin 10 in colorectal cancer (Review). Oncol Lett 13: 2449-2453, 2017
APA
Zhong, X., Shen, H., Mao, J., Zhang, J., & Han, W. (2017). Epigenetic silencing of protocadherin 10 in colorectal cancer (Review). Oncology Letters, 13, 2449-2453. https://doi.org/10.3892/ol.2017.5733
MLA
Zhong, X., Shen, H., Mao, J., Zhang, J., Han, W."Epigenetic silencing of protocadherin 10 in colorectal cancer (Review)". Oncology Letters 13.4 (2017): 2449-2453.
Chicago
Zhong, X., Shen, H., Mao, J., Zhang, J., Han, W."Epigenetic silencing of protocadherin 10 in colorectal cancer (Review)". Oncology Letters 13, no. 4 (2017): 2449-2453. https://doi.org/10.3892/ol.2017.5733