Open Access

Serum immunoreactivity of cancer/testis antigen OY-TES-1 and its tissues expression in glioma

  • Authors:
    • Xisheng Li
    • Jun Yan
    • Rong Fan
    • Bin Luo
    • Qingmei Zhang
    • Yongda Lin
    • Sufang Zhou
    • Guorong Luo
    • Xiaoxun Xie
    • Shaowen Xiao
  • View Affiliations

  • Published online on: March 3, 2017     https://doi.org/10.3892/ol.2017.5799
  • Pages: 3080-3086
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

OY-TES-1 is a member of the cancer/testis antigen family that is expressed in healthy testis tissue and certain types of cancerous tissue. The present study aimed to analyze the expression pattern of OY‑TES‑1 and serum anti-OY-TES-1 antibody concentration in patients with glioma. OY‑TES‑1 mRNA was detected in 28/36 (78%) of glioma cases using conventional reverse transcription polymerase chain reaction (RT‑PCR) analysis. RT‑quantitative‑PCR revealed that OY‑TES‑1 was expressed at a higher level in glioma tissues compared with normal adult tissues (with the exception of testis tissue). Anti-OY-TES-1 antibodies were present in the serum of 5/36 (14%) of patients with glioma, but absent in all the serum samples from 107 healthy donors. Immunohistochemical analysis demonstrated that OY‑TES‑1 protein was expressed in all glioma tissues from patients with anti‑OY‑TES‑1 antibody seropositivity. These results suggest that OY‑TES‑1 is a novel candidate for glioma immunotherapy.
View Figures
View References

Related Articles

Journal Cover

May-2017
Volume 13 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Li X, Yan J, Fan R, Luo B, Zhang Q, Lin Y, Zhou S, Luo G, Xie X, Xiao S, Xiao S, et al: Serum immunoreactivity of cancer/testis antigen OY-TES-1 and its tissues expression in glioma. Oncol Lett 13: 3080-3086, 2017
APA
Li, X., Yan, J., Fan, R., Luo, B., Zhang, Q., Lin, Y. ... Xiao, S. (2017). Serum immunoreactivity of cancer/testis antigen OY-TES-1 and its tissues expression in glioma. Oncology Letters, 13, 3080-3086. https://doi.org/10.3892/ol.2017.5799
MLA
Li, X., Yan, J., Fan, R., Luo, B., Zhang, Q., Lin, Y., Zhou, S., Luo, G., Xie, X., Xiao, S."Serum immunoreactivity of cancer/testis antigen OY-TES-1 and its tissues expression in glioma". Oncology Letters 13.5 (2017): 3080-3086.
Chicago
Li, X., Yan, J., Fan, R., Luo, B., Zhang, Q., Lin, Y., Zhou, S., Luo, G., Xie, X., Xiao, S."Serum immunoreactivity of cancer/testis antigen OY-TES-1 and its tissues expression in glioma". Oncology Letters 13, no. 5 (2017): 3080-3086. https://doi.org/10.3892/ol.2017.5799