Jak3 is involved in CCR7-dependent migration and invasion in metastatic squamous cell carcinoma of the head and neck

Corrigendum in: /10.3892/ol.2024.14712

  • Authors:
    • Zhongti Zhang
    • Fayu Liu
    • Zhenning Li
    • Dan Wang
    • Ruiwu Li
    • Changfu Sun
  • View Affiliations

  • Published online on: March 14, 2017     https://doi.org/10.3892/ol.2017.5861
  • Pages: 3191-3197
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Abstract

Patients with cervical lymph node metastasis in squamous cell carcinoma of the head and neck (SCCHN) exhibit a poor prognosis and low 5-year survival rate. It has been proven that chemokine receptor 7 (CCR7) promotes cellular migration and invasion in metastatic SCCHN. In the present study, the metastatic SCCHN PCI-37B cell line was utilized to explore the role of Janus activated kinase‑3 (Jak3) in the CCR7‑mediated signaling pathway in metastatic SCCHN cells. It was observed that phospho-Jak3 was expressed in SCCHN tissues. In addition, when the PCI‑37B cells were analyzed in response to chemokine ligand 19 (CCL19), the ligand of CCR7, at the indicated time points, the results of the present study demonstrated that CCR7 induced Jak3 activation, and inhibition of Jak3 activity using a specific inhibitor, ZM39923, significantly attenuated CCR7‑induced Jak3 phosphorylation. Migration and invasion assays and immunofluorescence staining experiments demonstrated that CCL19 promoted cell migration, invasion and F‑actin rearrangment in CCR7-expressing SCCHN cells partially due to the activation of the Jak3 signaling pathway. These results demonstrate that the Jak3 signaling pathway is important for the CCR7‑induced malignant biological behavior of SCCHN cells.
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May-2017
Volume 13 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhang Z, Liu F, Li Z, Wang D, Li R and Sun C: Jak3 is involved in CCR7-dependent migration and invasion in metastatic squamous cell carcinoma of the head and neck Corrigendum in /10.3892/ol.2024.14712. Oncol Lett 13: 3191-3197, 2017.
APA
Zhang, Z., Liu, F., Li, Z., Wang, D., Li, R., & Sun, C. (2017). Jak3 is involved in CCR7-dependent migration and invasion in metastatic squamous cell carcinoma of the head and neck Corrigendum in /10.3892/ol.2024.14712. Oncology Letters, 13, 3191-3197. https://doi.org/10.3892/ol.2017.5861
MLA
Zhang, Z., Liu, F., Li, Z., Wang, D., Li, R., Sun, C."Jak3 is involved in CCR7-dependent migration and invasion in metastatic squamous cell carcinoma of the head and neck Corrigendum in /10.3892/ol.2024.14712". Oncology Letters 13.5 (2017): 3191-3197.
Chicago
Zhang, Z., Liu, F., Li, Z., Wang, D., Li, R., Sun, C."Jak3 is involved in CCR7-dependent migration and invasion in metastatic squamous cell carcinoma of the head and neck Corrigendum in /10.3892/ol.2024.14712". Oncology Letters 13, no. 5 (2017): 3191-3197. https://doi.org/10.3892/ol.2017.5861