MicroRNA‑204 suppressed proliferation and motility capacity of human hepatocellular carcinoma via directly targeting zinc finger E‑box binding homeobox 2

  • Authors:
    • Bin Hu
    • Ming Sun
    • Jiajun Liu
    • Guolin Hong
    • Qin Lin
  • View Affiliations

  • Published online on: March 24, 2017     https://doi.org/10.3892/ol.2017.5907
  • Pages: 3823-3830
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Abstract

Abnormal expression levels of microRNA‑204 (miR‑204) have been identified in various types of human cancer. However, the expression and functions of miR‑204, and the underlying molecular mechanism involved in the initiation and progression of hepatocellular carcinoma (HCC), require further investigation. The results of the present study demonstrated that miR‑204 is downregulated in HCC tissues and cell lines. Notably, zinc finger E‑box binding homeobox 2 (ZEB2) was identified as a direct target of miR‑204 in HCC. In addition, miR‑204 negatively regulates ZEB2 expression level in HCC cells at the post‑transcriptional level. In functional studies, the overexpression of miR‑204 inhibited the proliferation, migration and invasion of HCC cells. Furthermore, the knockdown of ZEB2 may mimic the functions of miR‑204 in HCC cells, suggesting that ZEB2 is a direct functional target of miR‑204. In conclusion, the results of the present study indicated that miR‑204 suppresses the tumor growth, migration and invasion of HCC cells by directly targeting ZEB2, and may serve as a novel therapeutic target for HCC.
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May-2017
Volume 13 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Hu B, Sun M, Liu J, Hong G and Lin Q: MicroRNA‑204 suppressed proliferation and motility capacity of human hepatocellular carcinoma via directly targeting zinc finger E‑box binding homeobox 2. Oncol Lett 13: 3823-3830, 2017
APA
Hu, B., Sun, M., Liu, J., Hong, G., & Lin, Q. (2017). MicroRNA‑204 suppressed proliferation and motility capacity of human hepatocellular carcinoma via directly targeting zinc finger E‑box binding homeobox 2. Oncology Letters, 13, 3823-3830. https://doi.org/10.3892/ol.2017.5907
MLA
Hu, B., Sun, M., Liu, J., Hong, G., Lin, Q."MicroRNA‑204 suppressed proliferation and motility capacity of human hepatocellular carcinoma via directly targeting zinc finger E‑box binding homeobox 2". Oncology Letters 13.5 (2017): 3823-3830.
Chicago
Hu, B., Sun, M., Liu, J., Hong, G., Lin, Q."MicroRNA‑204 suppressed proliferation and motility capacity of human hepatocellular carcinoma via directly targeting zinc finger E‑box binding homeobox 2". Oncology Letters 13, no. 5 (2017): 3823-3830. https://doi.org/10.3892/ol.2017.5907