Expression of claudin 1, 4 and 7 in thyroid neoplasms

  • Authors:
    • Di̇nç Süren
    • Mustafa Yildirim
    • Alper Sayi̇ner
    • Arsenal Sezgi̇n Ali̇kanoğlu
    • İrem Atalay
    • Umut Riza Gündüz
    • Vi̇ldan Kaya
    • Şeyda Gündüz
    • Mehmet Tahi̇r Oruç
    • Cem Sezer
  • View Affiliations

  • Published online on: March 27, 2017     https://doi.org/10.3892/ol.2017.5916
  • Pages: 3722-3726
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Abstract

The distinction of thyroid carcinoma from benign thyroid neoplasm, as well as the subtyping of papillary carcinoma (PC) and follicular carcinoma (FC), may be performed histopathologically in the majority of cases. However, in certain cases, it is difficult to histopathologically distinguish between PC and FC, as well as follicular adenoma (FA), FC and the dominant nodule of multinodular goiter (MNG‑DN). The present study aimed to determine the roles of the expression levels of the tight junction proteins claudin 1, 4 and 7 in the differential diagnosis of PC, FC, FA, MNG‑DN, medullary carcinoma (MC) and anaplastic carcinoma (AC). The current study included 114 cases of histopathologically diagnosed thyroid neoplasia, which were distributed as follows: 29 FA, 18 MNG‑DN, 47 PC, 10 FC, 5 MC and 5 AC. The expression levels of claudin 1, 4 and 7 were examined using immunohistochemical methods. The results revealed a significant difference in claudin 1 expression between malignant and benign thyroid neoplasms (P<0.001). Claudin 1 expression was not detected in any of the MNG‑DN cases, and no significant difference in claudin 1 expression levels was identified between FA and FC (P=0.653). However, a statistically significant difference was observed between FC and PC (P<0.001). Claudin 4 expression did not differ between malignant and benign thyroid neoplasms, neither between MNG‑DN, FA and FC, nor between FC and PC (P=0.068, P=0.502 and P=0.481, respectively). Claudin 7 exhibited positive immunohistochemical staining in 107 patients (94%); however, no significant difference in claudin 7 expression §levels was identified between malignant and benign thyroid neoplasms among MNG‑DN, FA and FC (malignant, P=0.135; benign, P=0.470). Claudin 7 exhibited positive staining in all PC and FC cases. Therefore, claudin 1 expression levels may be useful in distinguishing cases of FC and PC with overlapping histopathological features, and provide a novel immunohistochemical marker for the subtyping of thyroid carcinoma.
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May-2017
Volume 13 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Süren D, Yildirim M, Sayi̇ner A, Ali̇kanoğlu AS, Atalay İ, Gündüz UR, Kaya V, Gündüz Ş, Oruç MT, Sezer C, Sezer C, et al: Expression of claudin 1, 4 and 7 in thyroid neoplasms. Oncol Lett 13: 3722-3726, 2017.
APA
Süren, D., Yildirim, M., Sayi̇ner, A., Ali̇kanoğlu, A.S., Atalay, İ., Gündüz, U.R. ... Sezer, C. (2017). Expression of claudin 1, 4 and 7 in thyroid neoplasms. Oncology Letters, 13, 3722-3726. https://doi.org/10.3892/ol.2017.5916
MLA
Süren, D., Yildirim, M., Sayi̇ner, A., Ali̇kanoğlu, A. S., Atalay, İ., Gündüz, U. R., Kaya, V., Gündüz, Ş., Oruç, M. T., Sezer, C."Expression of claudin 1, 4 and 7 in thyroid neoplasms". Oncology Letters 13.5 (2017): 3722-3726.
Chicago
Süren, D., Yildirim, M., Sayi̇ner, A., Ali̇kanoğlu, A. S., Atalay, İ., Gündüz, U. R., Kaya, V., Gündüz, Ş., Oruç, M. T., Sezer, C."Expression of claudin 1, 4 and 7 in thyroid neoplasms". Oncology Letters 13, no. 5 (2017): 3722-3726. https://doi.org/10.3892/ol.2017.5916