Open Access

Tumor necrosis factor-related apoptosis-inducing ligand inhibits proliferation and induces apoptosis of prostate and bladder cancer cells

  • Authors:
    • Lin Hao
    • Yan Zhao
    • Zhi-Gang Li
    • Hou-Guang He
    • Qing Liang
    • Zhi-Guo Zhang
    • Zhen-Duo Shi
    • Pei-Ying Zhang
    • Cong-Hui Han
  • View Affiliations

  • Published online on: March 27, 2017     https://doi.org/10.3892/ol.2017.5922
  • Pages: 3638-3640
  • Copyright: © Hao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The effect of recombinant and purified tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) on the proliferation and apoptosis of PC-3 prostate cancer cells and the 5637 bladder cancer cells were investigated. We used a cell proliferation assay and flow cytometry to measure the proliferation and apoptosis of cancer cells after 24-h incubation of PC-3 and 5637 cells with different concentrations of TRAIL. PC-3 cell proliferation rate significantly decreased when TRAIL was used at concentrations of 20, 40, 80 and 160 ng/ml compared with the untreated group. In the 5637 cells, the proliferation rate significantly decreased when TRAIL was used at concentrations of 5, 10, 20 and 40 ng/ml compared with the untreated group. The flow cytometry results also confirmed that the apoptosis rate of both cancer cell lines increased with TRAIL protein concentration. In conclusion, recombinant and purified TRAIL has anticancer activity by inhibiting proliferation and promoting apoptosis of prostate and bladder cancer cells.
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May-2017
Volume 13 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Hao L, Zhao Y, Li Z, He H, Liang Q, Zhang Z, Shi Z, Zhang P and Han C: Tumor necrosis factor-related apoptosis-inducing ligand inhibits proliferation and induces apoptosis of prostate and bladder cancer cells. Oncol Lett 13: 3638-3640, 2017
APA
Hao, L., Zhao, Y., Li, Z., He, H., Liang, Q., Zhang, Z. ... Han, C. (2017). Tumor necrosis factor-related apoptosis-inducing ligand inhibits proliferation and induces apoptosis of prostate and bladder cancer cells. Oncology Letters, 13, 3638-3640. https://doi.org/10.3892/ol.2017.5922
MLA
Hao, L., Zhao, Y., Li, Z., He, H., Liang, Q., Zhang, Z., Shi, Z., Zhang, P., Han, C."Tumor necrosis factor-related apoptosis-inducing ligand inhibits proliferation and induces apoptosis of prostate and bladder cancer cells". Oncology Letters 13.5 (2017): 3638-3640.
Chicago
Hao, L., Zhao, Y., Li, Z., He, H., Liang, Q., Zhang, Z., Shi, Z., Zhang, P., Han, C."Tumor necrosis factor-related apoptosis-inducing ligand inhibits proliferation and induces apoptosis of prostate and bladder cancer cells". Oncology Letters 13, no. 5 (2017): 3638-3640. https://doi.org/10.3892/ol.2017.5922