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Aggressiveness of the tall cell variant of papillary thyroid carcinoma is independent of the tumor size and patient age

  • Authors:
    • Rocío Villar‑Taibo
    • Diego Peteiro‑González
    • José Manuel Cabezas‑Agrícola
    • Elvin Aliyev
    • Francisco Barreiro‑Morandeira
    • Clara Ruiz‑Ponte
    • José M. Cameselle‑Teijeiro

  • View Affiliations

  • Published online on: March 29, 2017     https://doi.org/10.3892/ol.2017.5948
  • Pages: 3501-3507

  • Copyright: © Villar‑Taibo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The tall cell variant (TCV) of papillary thyroid carcinoma (PTC) is characterized by tall columnar cells with a height of at least three times their width. TCV usually presents at an older age, has a larger size and exhibits more extrathyroidal extension and metastases than classical PTC. The current study compared TCV with the classical and follicular variants (CaFVs) of PTC to determine if, irrespective of the age at diagnosis and tumor size, TCV is more aggressive than its classical and follicular counterparts. A total of 16 (3.66%) patients with TCV were identified in a series of 437 patients with PTC from the Clinical University Hospital (Santiago de Compostela, Spain) between 1990 and 2010. The patient clinicopathological features and B‑Raf proto‑oncogene (BRAF)V600E mutational status were compared with 34 cases of CaFVs of PTC matched for tumor size and patient age. The TCV series included 11 females and 5 males aged 15‑74 years (median, 57 years). In total, 15 (93.8%) patients underwent total or near‑total thyroidectomy, 1 underwent lobectomy and 5 (31.3%) underwent lymph node dissection. In the TCV series, the tumor size ranged from 5‑45 mm (median, 19 mm). Compared with the CaFVs, the TCV of PTC exhibited a significantly higher prevalence of extrathyroidal extension [9/16 (56.3%) vs. 5/34 (14.7%) cases; P=0.007], lymph node metastases [9/16 (56.3%) vs. 9/34 (26.4%) cases; P=0.04], stage III/IV at presentation [10/16 (62.5%) vs. 7/34 (20.5%) cases; P=0.009] and BRAFV600E mutation [12/16 (80.0%) vs. 7/25 (28.0%) cases; P=0.004]. The TCV series also harbored more multifocal papillary carcinomas (50.0% vs. 26.4%), lymphovascular invasion (37.5% vs. 29.4%) and distant metastases (6.2% vs. 0.0%), as compared with the matched patient cohort. In conclusion, the TCV of PTC is frequently associated with BRAFV600E mutation and is more aggressive than the CaFVs of PTC, regardless of tumor size and patient age at diagnosis.
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May-2017
Volume 13 Issue 5

Print ISSN: 1792-1074
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Spandidos Publications style
Villar‑Taibo R, Peteiro‑González D, Cabezas‑Agrícola JM, Aliyev E, Barreiro‑Morandeira F, Ruiz‑Ponte C and Cameselle‑Teijeiro JM: Aggressiveness of the tall cell variant of papillary thyroid carcinoma is independent of the tumor size and patient age. Oncol Lett 13: 3501-3507, 2017.
APA
Villar‑Taibo, R., Peteiro‑González, D., Cabezas‑Agrícola, J.M., Aliyev, E., Barreiro‑Morandeira, F., Ruiz‑Ponte, C., & Cameselle‑Teijeiro, J.M. (2017). Aggressiveness of the tall cell variant of papillary thyroid carcinoma is independent of the tumor size and patient age. Oncology Letters, 13, 3501-3507. https://doi.org/10.3892/ol.2017.5948
MLA
Villar‑Taibo, R., Peteiro‑González, D., Cabezas‑Agrícola, J. M., Aliyev, E., Barreiro‑Morandeira, F., Ruiz‑Ponte, C., Cameselle‑Teijeiro, J. M."Aggressiveness of the tall cell variant of papillary thyroid carcinoma is independent of the tumor size and patient age". Oncology Letters 13.5 (2017): 3501-3507.
Chicago
Villar‑Taibo, R., Peteiro‑González, D., Cabezas‑Agrícola, J. M., Aliyev, E., Barreiro‑Morandeira, F., Ruiz‑Ponte, C., Cameselle‑Teijeiro, J. M."Aggressiveness of the tall cell variant of papillary thyroid carcinoma is independent of the tumor size and patient age". Oncology Letters 13, no. 5 (2017): 3501-3507. https://doi.org/10.3892/ol.2017.5948