Open Access

High level of calpain1 promotes cancer cell invasion and migration in oral squamous cell carcinoma

  • Authors:
    • Da Ma
    • Juan Fang
    • Ying Liu
    • Jing‑Jing Song
    • Yan‑Qiong Wang
    • Juan Xia
    • Bin Cheng
    • Zhi Wang
  • View Affiliations

  • Published online on: April 3, 2017     https://doi.org/10.3892/ol.2017.5970
  • Pages: 4017-4026
  • Copyright: © Ma et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Calpain1, termed conventional calpain and a member of the Ca2+-dependent neutral cysteine proteases, is considered to be involved in cancer formation and development. However, the effect of calpain1 on oral squamous cell carcinoma (OSCC) remains poorly understood. The aim of the present study was to evaluate the possibility of calpain1 as a potential molecular target for OSCC diagnosis and therapy. The present study demonstrates that calpain1 was overexpressed in OSCC cell lines and 4/7 of the tumor tissues in paired samples of tumor and noncancerous matched tissues (NCMT). In a cohort of 125 patients with primary OSCC, the high expression of calpain1 was an independent predictor for overall survival in a multivariate analysis (P=0.022). Furthermore, RNA interference‑mediated suppression of calpain1 expression reduced the proliferation, migration and invasion potential of the HSC3 and CAL27 OSCC cell lines, but did not increase their apoptosis. These findings indicate that calpain1 may be a useful biomarker for novel prognostic and therapeutic strategies in oral squamous cell carcinoma.
View Figures
View References

Related Articles

Journal Cover

June-2017
Volume 13 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Ma D, Fang J, Liu Y, Song JJ, Wang YQ, Xia J, Cheng B and Wang Z: High level of calpain1 promotes cancer cell invasion and migration in oral squamous cell carcinoma. Oncol Lett 13: 4017-4026, 2017
APA
Ma, D., Fang, J., Liu, Y., Song, J., Wang, Y., Xia, J. ... Wang, Z. (2017). High level of calpain1 promotes cancer cell invasion and migration in oral squamous cell carcinoma. Oncology Letters, 13, 4017-4026. https://doi.org/10.3892/ol.2017.5970
MLA
Ma, D., Fang, J., Liu, Y., Song, J., Wang, Y., Xia, J., Cheng, B., Wang, Z."High level of calpain1 promotes cancer cell invasion and migration in oral squamous cell carcinoma". Oncology Letters 13.6 (2017): 4017-4026.
Chicago
Ma, D., Fang, J., Liu, Y., Song, J., Wang, Y., Xia, J., Cheng, B., Wang, Z."High level of calpain1 promotes cancer cell invasion and migration in oral squamous cell carcinoma". Oncology Letters 13, no. 6 (2017): 4017-4026. https://doi.org/10.3892/ol.2017.5970