Open Access

Effect of traditional Chinese medicine components on multidrug resistance in tumors mediated by P-glycoprotein (Review)

  • Authors:
    • Xi Xia
    • Susan P.C. Cole
    • Tiange Cai
    • Yu Cai
  • View Affiliations

  • Published online on: April 3, 2017     https://doi.org/10.3892/ol.2017.5976
  • Pages: 3989-3996
  • Copyright: © Xia et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Multidrug resistance (MDR) is a major cause of chemotherapy failure. It occurs when an organism is resistant to one type of drug, but also develops resistance to other drugs with different structures and targets. There is a high incidence of MDR in cancer chemotherapy, therefore, finding an effective and non‑toxic MDR reversal agent is an important goal, particularly for P-glycoprotein-mediated MDR in cancer. Improvements continue to be made to the status and understanding of traditional Chinese medicine (TCM), due to the advantages of low toxicity and relatively minor side effects. Therefore TCM is currently being used in the treatment of various types of diseases. In recent years, numerous components of TCM have been identified to be effective in reversing MDR by downregulating expression of the drug transporter membrane protein, recovering changes in enzymes involved in detoxification and metabolism and repairing the cell apoptosis pathway. The present study summarizes the anticancerous properties and MDR reversing components of traditional medicinal plants commonly used in the treatment of cancer.
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June-2017
Volume 13 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Xia X, Cole SP, Cai T and Cai Y: Effect of traditional Chinese medicine components on multidrug resistance in tumors mediated by P-glycoprotein (Review). Oncol Lett 13: 3989-3996, 2017
APA
Xia, X., Cole, S.P., Cai, T., & Cai, Y. (2017). Effect of traditional Chinese medicine components on multidrug resistance in tumors mediated by P-glycoprotein (Review). Oncology Letters, 13, 3989-3996. https://doi.org/10.3892/ol.2017.5976
MLA
Xia, X., Cole, S. P., Cai, T., Cai, Y."Effect of traditional Chinese medicine components on multidrug resistance in tumors mediated by P-glycoprotein (Review)". Oncology Letters 13.6 (2017): 3989-3996.
Chicago
Xia, X., Cole, S. P., Cai, T., Cai, Y."Effect of traditional Chinese medicine components on multidrug resistance in tumors mediated by P-glycoprotein (Review)". Oncology Letters 13, no. 6 (2017): 3989-3996. https://doi.org/10.3892/ol.2017.5976