Open Access

MAPK/P53-mediated FASN expression in bone tumors

  • Authors:
    • Ye Jiang
    • Xiaofan Yin
    • Liang Wu
    • Qiang Qin
    • Jun Xu
  • View Affiliations

  • Published online on: April 10, 2017     https://doi.org/10.3892/ol.2017.6015
  • Pages: 4035-4038
  • Copyright: © Jiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The correlation between mitogen-activated protein kinase (MAPK)/P53 signaling-dependent fatty acid synthase (FASN) expression and bone tumors was examined in the present study. We established the SH081 bone tumor cell line, which was used to determine the expression of FASN and MAPK/P53 at the mRNA and protein levels in bone tumor cells and normal cells. Compared with the normal cells, the expression of MAPK/P53 and FASN mRNA was significantly elevated, whereas inhibition of MAPK/P53 decreased FASN expression. Similarly, the expression of FASN and MAPK/P53 proteins were significantly elevated in the bone tumor cells and treatment with the MAPK/P53 inhibitor decreased the expression of FASN. To determine the role of MAPK/P53 in cell proliferation, bone cancer cells were treated with MAPK/P53 inhibitor and the results showed a reduced proliferation rate. Thus, FASN promotes the development of bone tumors and MAPK/P53 signaling contributes to bone tumors by upregulating the expression of FASN.
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June-2017
Volume 13 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Jiang Y, Yin X, Wu L, Qin Q and Xu J: MAPK/P53-mediated FASN expression in bone tumors. Oncol Lett 13: 4035-4038, 2017
APA
Jiang, Y., Yin, X., Wu, L., Qin, Q., & Xu, J. (2017). MAPK/P53-mediated FASN expression in bone tumors. Oncology Letters, 13, 4035-4038. https://doi.org/10.3892/ol.2017.6015
MLA
Jiang, Y., Yin, X., Wu, L., Qin, Q., Xu, J."MAPK/P53-mediated FASN expression in bone tumors". Oncology Letters 13.6 (2017): 4035-4038.
Chicago
Jiang, Y., Yin, X., Wu, L., Qin, Q., Xu, J."MAPK/P53-mediated FASN expression in bone tumors". Oncology Letters 13, no. 6 (2017): 4035-4038. https://doi.org/10.3892/ol.2017.6015