Open Access

A low serum Tat-interacting protein 30 level is a diagnostic and prognostic biomarker for hepatocellular carcinoma

  • Authors:
    • Sha‑Sha Fan
    • Chu‑Shu Liao
    • You‑De Cao
    • Pei‑Ling Xiao
    • Tan Deng
    • Rong‑Cheng Luo
    • Hua‑Xin Duan
  • View Affiliations

  • Published online on: April 11, 2017     https://doi.org/10.3892/ol.2017.6024
  • Pages: 4208-4214
  • Copyright: © Fan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study aimed to evaluate the diagnostic and prognostic value of Tat‑interacting protein 30 (HTATIP2/TIP30) levels alone and in combination with α-fetoprotein (AFP) for the evaluation of hepatocellular carcinoma (HCC) patients. ELISA and immunohistochemical measurements on the serum and tissue of HTATIP2/TIP30 protein from HCC patients and normal controls were made. Receiver operating characteristic (ROC) curve analyses of AFP and HTATIP2/TIP30 were performed, as well as logistic regression analysis of APF combined with HTATIP2/TIP30. Log‑rank analysis was used to correlate the prognosis with various levels of HTATIP2/TIP30. HTATIP2/TIP30 levels were significantly lower in the HCC group compared with the control group (4.50±2.63 vs. 9.50±2.04 ng/ml, P<0.001). ROC analysis revealed an optimal cut‑off point at 7.27 ng/ml HTATIP2/TIP30 for separating the HCC from the control groups. The sensitivity and specificity were 84.6 and 93.7% (P<0.001), respectively. ROC areas of HTATIP2/TIP30 (0.928, P<0.001) were significantly higher than those for AFP (P<0.001). The area under the curve of the HTATIP2/TIP30 and AFP combination was 0.950 (P<0.001). Log‑rank tests revealed that the recurrence‑free survival time of the group with HTATIP2/TIP30>5.71 ng/ml was significantly higher than that of the control group (P<0.001). This is the first study to demonstrate that HTATIP2/TIP30 levels in serum may be an effective biomarker for the diagnosis and prognosis of HCC.
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June-2017
Volume 13 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Fan SS, Liao CS, Cao YD, Xiao PL, Deng T, Luo RC and Duan HX: A low serum Tat-interacting protein 30 level is a diagnostic and prognostic biomarker for hepatocellular carcinoma. Oncol Lett 13: 4208-4214, 2017.
APA
Fan, S., Liao, C., Cao, Y., Xiao, P., Deng, T., Luo, R., & Duan, H. (2017). A low serum Tat-interacting protein 30 level is a diagnostic and prognostic biomarker for hepatocellular carcinoma. Oncology Letters, 13, 4208-4214. https://doi.org/10.3892/ol.2017.6024
MLA
Fan, S., Liao, C., Cao, Y., Xiao, P., Deng, T., Luo, R., Duan, H."A low serum Tat-interacting protein 30 level is a diagnostic and prognostic biomarker for hepatocellular carcinoma". Oncology Letters 13.6 (2017): 4208-4214.
Chicago
Fan, S., Liao, C., Cao, Y., Xiao, P., Deng, T., Luo, R., Duan, H."A low serum Tat-interacting protein 30 level is a diagnostic and prognostic biomarker for hepatocellular carcinoma". Oncology Letters 13, no. 6 (2017): 4208-4214. https://doi.org/10.3892/ol.2017.6024