MicroRNA-10b inhibits proliferation, migration and invasion in cervical cancer cells via direct targeting of insulin-like growth factor-1 receptor

  • Authors:
    • Ren Hou
    • Daixian Wang
    • Jian Lu
  • View Affiliations

  • Published online on: April 13, 2017     https://doi.org/10.3892/ol.2017.6033
  • Pages: 5009-5015
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Abstract

MicroRNAs are deregulated in numerous types of human cancers and have crucial roles in the carcinogenesis and progression of human cancers. MicroRNA-10b (miR-10b) has been studied in several types of human cancer. However, the expression and roles of miR‑10b in cervical cancer remain unknown. In the present study, the expression, functions and molecular mechanisms of miR‑10b were explored in cervical cancer. The present data revealed that miR‑10b was significantly downregulated in cervical cancer tissues and cell lines. In addition, miR‑10b overexpression inhibited the proliferation, migration and invasion of cervical cancer cells, while miR‑10b under‑expression had the opposite effect. Based on bioinformatics analysis, a luciferase reporter assay and western blot analysis, insulin‑like growth factor‑1 receptor (IGF‑1R) was identified as a direct target of miR‑10b in cervical cancer. In addition, IGF‑1R small interfering RNA‑mediated knockdown of IGF‑1R also inhibited the proliferation, migration and invasion of the cervical cancer cells. In conclusion, the present study demonstrated that miR‑10b serves an important role in cervical cancer progression by targeting IGF-1R.
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June-2017
Volume 13 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Hou R, Wang D and Lu J: MicroRNA-10b inhibits proliferation, migration and invasion in cervical cancer cells via direct targeting of insulin-like growth factor-1 receptor. Oncol Lett 13: 5009-5015, 2017
APA
Hou, R., Wang, D., & Lu, J. (2017). MicroRNA-10b inhibits proliferation, migration and invasion in cervical cancer cells via direct targeting of insulin-like growth factor-1 receptor. Oncology Letters, 13, 5009-5015. https://doi.org/10.3892/ol.2017.6033
MLA
Hou, R., Wang, D., Lu, J."MicroRNA-10b inhibits proliferation, migration and invasion in cervical cancer cells via direct targeting of insulin-like growth factor-1 receptor". Oncology Letters 13.6 (2017): 5009-5015.
Chicago
Hou, R., Wang, D., Lu, J."MicroRNA-10b inhibits proliferation, migration and invasion in cervical cancer cells via direct targeting of insulin-like growth factor-1 receptor". Oncology Letters 13, no. 6 (2017): 5009-5015. https://doi.org/10.3892/ol.2017.6033