An unusual case of pseudomyxoma peritonei associated with synchronous primary mucinous tumors of the ovary and appendix: A case report

Suh,Dong  Soo; Song,Yong  Jung; Kwon,Byung  Su; Lee,Sul; Lee,Nam  Kyung; Choi,Kyung  Un; Kim,Ki  Hyung

doi:10.3892/ol.2017.6079

An unusual case of pseudomyxoma peritonei associated with synchronous primary mucinous tumors of the ovary and appendix: A case report

Authors:
- Dong Soo Suh
- Yong Jung Song
- Byung Su Kwon
- Sul Lee
- Nam Kyung Lee
- Kyung Un Choi
- Ki Hyung Kim
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Affiliations: Department of Obstetrics and Gynecology, Pusan National University School of Medicine, Busan 49241, Republic of Korea, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, South Gyeongsangnam 50612, Republic of Korea, Biomedical Research Institute and Pusan Cancer Center, Pusan National University Hospital, Busan 49241, Republic of Korea, Department of Pathology, Pusan National University School of Medicine, Busan 49241, Republic of Korea
Published online on: April 24, 2017 https://doi.org/10.3892/ol.2017.6079
Pages: 4813-4817
Copyright: © Suh et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Pseudomyxoma peritonei (PMP) is a rare disease that usually originates from mucinous neoplasms of the appendix and, less commonly, from extra‑appendiceal tumors, but it may also be caused by synchronous primary mucinous tumors of the ovary and appendix. The current study discusses the case of a 73‑year‑old female who presented with progressively worsening indigestion and abdominal distension. Magnetic resonance imaging of the pelvis revealed a large cystic mass with a thin enhancing septa arising from the right ovary and ascites with scalloping of the liver surface. On laparotomy, the patient was observed to have a large ruptured mass on the right ovary and a partially amputed distended appendix filled with mucin. The subsequent pathology report confirmed a borderline mucinous tumor of the right ovary and a low‑grade appendiceal mucinous neoplasm associated with PMP. Immunohistochemical examination demonstrated the ovarian tumor stained strongly positive for cytokeratin (CK)‑7, and negatively for CK‑20 and homeobox protein CDX‑2 (CDX2), whereas the appendiceal tumor stained negative for CK‑7 and positive for CK‑20 and CDX2. This study presents a rare case of PMP caused by synchronous primary mucinous tumors of the ovary and appendix in a postmenopausal female.

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