Open Access

Prevalence and clinical significance of mediator complex subunit 12 mutations in 362 Han Chinese samples with uterine leiomyoma

  • Authors:
    • Juan Wu
    • Yang Zou
    • Yong Luo
    • Jiu‑Bai Guo
    • Fa‑Ying Liu
    • Jiang‑Yan Zhou
    • Zi‑Yu Zhang
    • Lei Wan
    • Ou‑Ping Huang
  • View Affiliations

  • Published online on: May 4, 2017     https://doi.org/10.3892/ol.2017.6120
  • Pages: 47-54
  • Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Uterine leiomyomas (ULs) are the most common gynecological benign tumors originating from the myometrium. Prevalent mutations in the mediator complex subunit 12 (MED12) gene have been identified in ULs, and functional evidence has revealed that these mutations may promote the development of ULs. However, whether MED12 mutations are associated with certain clinical characteristics in ULs remains largely unknown. In the present study, the potential mutations of MED12 and its paralogous gene, mediator complex subunit 12‑like (MED12L), were screened in 362 UL tumors from Han Chinese patients. A total of 158 out of 362 UL tumors (43.6%) were identified as harboring MED12 somatic mutations, and the majority of these mutations were restricted to the 44th residue. MED12 mutations were also observed in 2 out of 145 (1.4%) adjacent control myometrium. Furthermore, the mutation spectrum of MED12 in the concurrent leiomyomas was noticeably different. Correlation analysis of MED12 mutations with the available clinical features indicated that patients with mutated MED12 tended to have smaller cervical diameters. By contrast, no MED12L mutation was identified in the present samples. In summary, the present study demonstrated the presence of prevalent MED12 somatic mutations in UL samples, and the MED12 mutation was associated with smaller cervical diameters. The low mutation frequency of MED12 in adjacent control myometrium indicated that MED12 mutation may be an early event in the pathogenesis of ULs. Furthermore, MED12 mutation status in concurrent tumors from multiple leiomyomas supported several prior observations that the majority of these tumors arose independently.
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July-2017
Volume 14 Issue 1

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Spandidos Publications style
Wu J, Zou Y, Luo Y, Guo JB, Liu FY, Zhou JY, Zhang ZY, Wan L and Huang OP: Prevalence and clinical significance of mediator complex subunit 12 mutations in 362 Han Chinese samples with uterine leiomyoma. Oncol Lett 14: 47-54, 2017.
APA
Wu, J., Zou, Y., Luo, Y., Guo, J., Liu, F., Zhou, J. ... Huang, O. (2017). Prevalence and clinical significance of mediator complex subunit 12 mutations in 362 Han Chinese samples with uterine leiomyoma. Oncology Letters, 14, 47-54. https://doi.org/10.3892/ol.2017.6120
MLA
Wu, J., Zou, Y., Luo, Y., Guo, J., Liu, F., Zhou, J., Zhang, Z., Wan, L., Huang, O."Prevalence and clinical significance of mediator complex subunit 12 mutations in 362 Han Chinese samples with uterine leiomyoma". Oncology Letters 14.1 (2017): 47-54.
Chicago
Wu, J., Zou, Y., Luo, Y., Guo, J., Liu, F., Zhou, J., Zhang, Z., Wan, L., Huang, O."Prevalence and clinical significance of mediator complex subunit 12 mutations in 362 Han Chinese samples with uterine leiomyoma". Oncology Letters 14, no. 1 (2017): 47-54. https://doi.org/10.3892/ol.2017.6120