Open Access

Transrectal real-time tissue elastography targeted biopsy coupled with peak strain index improves the detection of clinically important prostate cancer

  • Authors:
    • Qi Ma
    • Dong‑Rong Yang
    • Bo‑Xin Xue
    • Cheng Wang
    • Han‑Bin Chen
    • Yun Dong
    • Cai‑Shan Wang
    • Yu‑Xi Shan
  • View Affiliations

  • Published online on: May 5, 2017     https://doi.org/10.3892/ol.2017.6126
  • Pages: 210-216
  • Copyright: © Ma et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The focus of the present study was to evaluate transrectal real‑time tissue elastography (RTE)‑targeted two‑core biopsy coupled with peak strain index for the detection of prostate cancer (PCa) and to compare this method with 10‑core systematic biopsy. A total of 141 patients were enrolled for evaluation. The diagnostic value of peak strain index was assessed using a receiver operating characteristic curve. The cancer detection rates of the two approaches and corresponding positive cores and Gleason score were compared. The cancer detection rate per core in the RTE‑targeted biopsy (44%) was higher compared with that in systematic biopsy (30%). The peak strain index value of PCa was higher compared with that of the benign lesion. PCa was detected with the highest sensitivity (87.5%) and specificity (85.5%) using the threshold value of a peak strain index of ≥5.97 with an area under the curve value of 0.95. When the Gleason score was ≥7, RTE‑targeted biopsy coupled with peak strain index detected 95.6% of PCa cases, but 84.4% were detected using systematic biopsy. Peak strain index as a quantitative parameter may improve the differentiation of PCa from benign lesions in the prostate peripheral zone. Transrectal RTE‑targeted biopsy coupled with peak strain index may enhance the detection of clinically significant PCa, particularly when combined with systematic biopsy.
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July-2017
Volume 14 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Ma Q, Yang DR, Xue BX, Wang C, Chen HB, Dong Y, Wang CS and Shan YX: Transrectal real-time tissue elastography targeted biopsy coupled with peak strain index improves the detection of clinically important prostate cancer. Oncol Lett 14: 210-216, 2017.
APA
Ma, Q., Yang, D., Xue, B., Wang, C., Chen, H., Dong, Y. ... Shan, Y. (2017). Transrectal real-time tissue elastography targeted biopsy coupled with peak strain index improves the detection of clinically important prostate cancer. Oncology Letters, 14, 210-216. https://doi.org/10.3892/ol.2017.6126
MLA
Ma, Q., Yang, D., Xue, B., Wang, C., Chen, H., Dong, Y., Wang, C., Shan, Y."Transrectal real-time tissue elastography targeted biopsy coupled with peak strain index improves the detection of clinically important prostate cancer". Oncology Letters 14.1 (2017): 210-216.
Chicago
Ma, Q., Yang, D., Xue, B., Wang, C., Chen, H., Dong, Y., Wang, C., Shan, Y."Transrectal real-time tissue elastography targeted biopsy coupled with peak strain index improves the detection of clinically important prostate cancer". Oncology Letters 14, no. 1 (2017): 210-216. https://doi.org/10.3892/ol.2017.6126