MicroRNA‑125b targeted STAT3 to inhibit laryngeal squamous cell carcinoma cell growth and motility

  • Authors:
    • Juan Feng
    • Yuqin Fan
    • Qukuerhan Ayiheng
    • Hua Zhang
    • Jun Yong
    • Bin Hu
  • View Affiliations

  • Published online on: May 11, 2017     https://doi.org/10.3892/ol.2017.6155
  • Pages: 480-486
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

A majority of studies have indicated that microRNA‑125b (miR‑125b) is aberrantly expressed in various types of cancer. However, there are no studies on the expression and function of miR‑125b in human laryngeal squamous cell carcinoma (LSCC). In the present study, miR‑125b expression in LSCC sample tissues, corresponding adjacent non‑neoplastic tissues, LSCC cell lines and a normal human keratinocyte cell line was measured using the reverse transcription‑quantitative polymerase chain reaction. Following transfection with miR‑125b mimics, the Cell Counting Kit‑8, cell migration, cell invasion, western blotting and dual‑luciferase reporter assays were performed on LSCC cell lines. According to the results, miR‑125b was observed to be significantly downregulated in LSCC, and its expression was significantly associated with clinical stage and alcohol history. miR‑125b was also observed to decrease cell growth, migra­tion and invasion in LSCC cells by directly targeting signal transducer and activator of transcription 3. The results of the present study suggested that miR‑125b may be a potential treatment target of LSCC in the future.
View Figures
View References

Related Articles

Journal Cover

July-2017
Volume 14 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Feng J, Fan Y, Ayiheng Q, Zhang H, Yong J and Hu B: MicroRNA‑125b targeted STAT3 to inhibit laryngeal squamous cell carcinoma cell growth and motility. Oncol Lett 14: 480-486, 2017.
APA
Feng, J., Fan, Y., Ayiheng, Q., Zhang, H., Yong, J., & Hu, B. (2017). MicroRNA‑125b targeted STAT3 to inhibit laryngeal squamous cell carcinoma cell growth and motility. Oncology Letters, 14, 480-486. https://doi.org/10.3892/ol.2017.6155
MLA
Feng, J., Fan, Y., Ayiheng, Q., Zhang, H., Yong, J., Hu, B."MicroRNA‑125b targeted STAT3 to inhibit laryngeal squamous cell carcinoma cell growth and motility". Oncology Letters 14.1 (2017): 480-486.
Chicago
Feng, J., Fan, Y., Ayiheng, Q., Zhang, H., Yong, J., Hu, B."MicroRNA‑125b targeted STAT3 to inhibit laryngeal squamous cell carcinoma cell growth and motility". Oncology Letters 14, no. 1 (2017): 480-486. https://doi.org/10.3892/ol.2017.6155