Dermatofibrosarcoma protuberans of the breast:  A case report

Pohlodek,Kamil; Mečiarová,Iveta; Grossmann,Petr; Kinkor,Zdeněk

doi:10.3892/ol.2017.6206

Dermatofibrosarcoma protuberans of the breast: A case report

Authors:
- Kamil Pohlodek
- Iveta Mečiarová
- Petr Grossmann
- Zdeněk Kinkor
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Affiliations: The Second Department of Gynecology and Obstetrics, Faculty of Medicine, Comenius University of Bratislava, 82606 Bratislava, Slovakia, Alpha Medical Pathology, Ltd., 84101 Bratislava, Slovakia, Department of Pathology, Faculty of Medicine in Plzeň, Charles University in Prague, 32300 Plzeň, Czech Republic
Published online on: May 19, 2017 https://doi.org/10.3892/ol.2017.6206
Pages: 993-998
Copyright: © Pohlodek et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Dermatofibrosarcoma protuberans (DFSP) is a rare malignant tumor of subcutaneous tissue characterized by slow infiltrative growth. The tumor occurs in patients of all ages, with the highest frequency occurring between the second and the fifth decades of age. Genetically, DFSP is characterized by a reciprocal translocation t(17;22)(q22;q13), or more often, as a supernumerary ring chromosome involving chromosomes 17 and 22. Standard treatment of a localized tumor is surgical excision with wide margins. In the present study, a case report of a 43‑year‑old woman with a growing tumor in the left breast is discussed. The patient underwent breast‑conserving surgery. Histological and cytogenetic examinations of the tumor resulted in a diagnosis of DFSP. The clinical and morphological characteristics of the tumor, in addition to the treatment options, were also evaluated.

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