Open Access

Primary oral malignant melanoma metastasis to the brain and breast: A case report and literature review

  • Authors:
    • Saad Alqahtani
    • Amal Y. Alhefdhi
    • Osama Almalik
    • Ihab Anwar
    • Rana Mahmood
    • Zeyad Mahasin
    • Taher Al‑Tweigeri
  • View Affiliations

  • Published online on: June 2, 2017     https://doi.org/10.3892/ol.2017.6304
  • Pages: 1275-1280
  • Copyright: © Alqahtani et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Primary oral malignant melanoma is a rare tumor, which is estimated to comprise 0.2‑8.0% of all melanoma cases. This type of cancer is fairly uncommon, its prognosis is dismal, and it frequently exhibits a biologically aggressive behavior. The common location of primary oral malignant melanoma is the hard palate and maxillary alveolus. In ~85% of cases, the melanoma will metastasize to the liver, lung, bone and brain early in the course of the disease. The present study reports the case of a 50‑year‑old premenopausal woman who presented with primary oral malignant spindle cell melanoma (T3bN2aM0) and underwent complete surgical resection followed by an adjuvant course of radiation therapy. After 1 year, the patient presented with sudden onset slurred speech, and upon examination, was found to have left‑sided hemiparesis and a hard left breast mass. Workup confirmed breast and brain metastasis. The patient developed lung metastasis 4 weeks later and was referred for palliative care.
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August-2017
Volume 14 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Alqahtani S, Alhefdhi AY, Almalik O, Anwar I, Mahmood R, Mahasin Z and Al‑Tweigeri T: Primary oral malignant melanoma metastasis to the brain and breast: A case report and literature review. Oncol Lett 14: 1275-1280, 2017
APA
Alqahtani, S., Alhefdhi, A.Y., Almalik, O., Anwar, I., Mahmood, R., Mahasin, Z., & Al‑Tweigeri, T. (2017). Primary oral malignant melanoma metastasis to the brain and breast: A case report and literature review. Oncology Letters, 14, 1275-1280. https://doi.org/10.3892/ol.2017.6304
MLA
Alqahtani, S., Alhefdhi, A. Y., Almalik, O., Anwar, I., Mahmood, R., Mahasin, Z., Al‑Tweigeri, T."Primary oral malignant melanoma metastasis to the brain and breast: A case report and literature review". Oncology Letters 14.2 (2017): 1275-1280.
Chicago
Alqahtani, S., Alhefdhi, A. Y., Almalik, O., Anwar, I., Mahmood, R., Mahasin, Z., Al‑Tweigeri, T."Primary oral malignant melanoma metastasis to the brain and breast: A case report and literature review". Oncology Letters 14, no. 2 (2017): 1275-1280. https://doi.org/10.3892/ol.2017.6304