Primary oral malignant melanoma metastasis to the brain and breast: A case report and literature review

Alqahtani,Saad; Alhefdhi,Amal  Y.; Almalik,Osama; Anwar,Ihab; Mahmood,Rana; Mahasin,Zeyad; Al‑Tweigeri,Taher

doi:10.3892/ol.2017.6304

Primary oral malignant melanoma metastasis to the brain and breast: A case report and literature review

Authors:
- Saad Alqahtani
- Amal Y. Alhefdhi
- Osama Almalik
- Ihab Anwar
- Rana Mahmood
- Zeyad Mahasin
- Taher Al‑Tweigeri
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Affiliations: Department of Surgery, College of Medicine, Al Majmaah University, Academic City, Al Majmaah 15341, Kingdom of Saudi Arabia, Department of General Surgery, King Faisal Specialist Hospital and Research Centre, Alfaisal University, Riyadh 11211, Kingdom of Saudi Arabia, Department of Radiation Oncology, Oncology Center, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Kingdom of Saudi Arabia, Department of Otolaryngology, Head and Neck Surgery and Communication, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Kingdom of Saudi Arabia, Department of Medical Oncology, Oncology Center, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Kingdom of Saudi Arabia
Published online on: June 2, 2017 https://doi.org/10.3892/ol.2017.6304
Pages: 1275-1280
Copyright: © Alqahtani et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Primary oral malignant melanoma is a rare tumor, which is estimated to comprise 0.2‑8.0% of all melanoma cases. This type of cancer is fairly uncommon, its prognosis is dismal, and it frequently exhibits a biologically aggressive behavior. The common location of primary oral malignant melanoma is the hard palate and maxillary alveolus. In ~85% of cases, the melanoma will metastasize to the liver, lung, bone and brain early in the course of the disease. The present study reports the case of a 50‑year‑old premenopausal woman who presented with primary oral malignant spindle cell melanoma (T3bN2aM0) and underwent complete surgical resection followed by an adjuvant course of radiation therapy. After 1 year, the patient presented with sudden onset slurred speech, and upon examination, was found to have left‑sided hemiparesis and a hard left breast mass. Workup confirmed breast and brain metastasis. The patient developed lung metastasis 4 weeks later and was referred for palliative care.

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