Association of p73 gene G4C14-A4T14 polymorphism and MDM2 gene SNP309 with non-small cell lung cancer risk in a Chinese population

  • Authors:
    • Wen Li
    • Shuang Shuang Wang
    • Jing Deng
    • Jian Xin Tang
  • View Affiliations

  • Published online on: June 7, 2017     https://doi.org/10.3892/ol.2017.6327
  • Pages: 1817-1822
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Abstract

The present study aimed to investigate the association of p73 G4C14-A4T14 polymorphism and murine double minute 2 (MDM2) 309 T/G single nucleotide polymorphisms (SNPs) with the risk of developing non‑small cell lung cancer (NSCLC) in Sothern China. The p73 and MDM2 genotypes of peripheral blood DNA from 186 patients with NSCLC and 196 normal controls were detected by polymerase chain reaction (PCR) with confronting two‑pair primers (CTPP) and high resolution melting (HRM), respectively. The results of genotyping were consistent with those of direct sequencing. The p73 AT/AT [odds ratio (OR)=0.46; 95% confidence interval (CI)=0.22‑0.97] and MDM2 TT (OR=0.48; 95% CI=0.26‑0.86) genotypes were associated with a decreased risk of developing NSCLC compared with that of the p73 GC/GC and MDM2 GG genotypes, respectively. In addition, the interaction between the p73 and MDM2 polymorphisms reduced the risk of developing NSCLC in multiple ways (OR=0.13; 95% CI=0.03‑0.59) for subjects carrying both the p73 AT/AT and MDM2 TT genotypes. Therefore, the SNP in p73 G4C14‑A4T14 and the MDM2 309 polymorphism may be markers of genetic susceptibility to NSCLC in a Chinese population, and there is a possible gene‑gene interaction involved in the incidence of NSCLC.
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August-2017
Volume 14 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Li W, Wang SS, Deng J and Tang JX: Association of p73 gene G4C14-A4T14 polymorphism and MDM2 gene SNP309 with non-small cell lung cancer risk in a Chinese population. Oncol Lett 14: 1817-1822, 2017
APA
Li, W., Wang, S.S., Deng, J., & Tang, J.X. (2017). Association of p73 gene G4C14-A4T14 polymorphism and MDM2 gene SNP309 with non-small cell lung cancer risk in a Chinese population. Oncology Letters, 14, 1817-1822. https://doi.org/10.3892/ol.2017.6327
MLA
Li, W., Wang, S. S., Deng, J., Tang, J. X."Association of p73 gene G4C14-A4T14 polymorphism and MDM2 gene SNP309 with non-small cell lung cancer risk in a Chinese population". Oncology Letters 14.2 (2017): 1817-1822.
Chicago
Li, W., Wang, S. S., Deng, J., Tang, J. X."Association of p73 gene G4C14-A4T14 polymorphism and MDM2 gene SNP309 with non-small cell lung cancer risk in a Chinese population". Oncology Letters 14, no. 2 (2017): 1817-1822. https://doi.org/10.3892/ol.2017.6327