Desmoid-type fibromatosis of the breast: A report of 2 cases

Benej,Roman; Mečiarová,Iveta; Pohlodek,Kamil

doi:10.3892/ol.2017.6337

Desmoid-type fibromatosis of the breast: A report of 2 cases

Authors:
- Roman Benej
- Iveta Mečiarová
- Kamil Pohlodek
View Affiliations

Affiliations: Department of Thoracic Surgery, Slovak Medical University of Bratislava, 82606 Bratislava, Slovakia, Alpha Medical Pathology, Ltd., 84101 Bratislava, Slovakia, Second Department of Gynecology and Obstetrics, Comenius University of Bratislava, Faculty of Medicine, 82606 Bratislava, Slovakia
Published online on: June 7, 2017 https://doi.org/10.3892/ol.2017.6337
Pages: 1433-1438
Copyright: © Benej et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

Mammary fibromatosis is a rare and locally aggressive benign tumor of the breast; it originates from fibroblasts and myofibroblasts within the breast parenchyma and does not metastasize. The condition is locally aggressive and has a high rate of recurrence. The etiology of mammary fibromatosis is unknown. Breast imaging examinations are not specific for fibromatosis and often imitate breast cancer. The current study presents 2 cases of women with breast fibromatosis, the first of which exhibited a locally advanced aggressive form of the disease, where breast surgery and en bloc resection of the underlying regions of the thoracic wall were required. In the second case, breast imaging examinations suggested an invasive breast tumor, probably carcinoma, infiltrating the muscles of the chest wall. An ultrasound‑guided core needle biopsy revealed a low‑grade myofibroblastic proliferation consistent with breast fibromatosis. The patient underwent a right quadrantectomy, with a partial resection of the underlying musculature. The patients remain disease‑free at the time of writing. As involvement of the breast in patients with desmoid‑like fibromatosis as rare, the present study reports 2 cases with clinical features and histological findings in order to improve and add to the knowledge of this disease.

View Figures

View References

1	Eastley N, McCulloch T, Esler C, Hennig I, Fairbairn J, Gronchi A and Ashford R: Extra-abdominal desmoid fibromatosis: A review of management, current guidance and unanswered questions. Eur J Surg Oncol. 42:1071–1083. 2016. View Article : Google Scholar : PubMed/NCBI
2	Povoski SP, Marsh WL Jr, Spigos DG, Abbas EA and Buchele BA: Management of a patient with multiple recurrences of fibromatosis (desmoid tumor) of the breast involving the chest wall musculature. World J Surg Oncol. 4:322006. View Article : Google Scholar : PubMed/NCBI
3	Shen C, Zhou Y and Che G: Management of a female with recurrence of fibromatosis of the chest wall adjacent to the breast: A case report. J Cardiothorac Surg. 8:412013. View Article : Google Scholar : PubMed/NCBI
4	Abbas AE, Deschamps C, Cassivi SD, Nichols FC III, Allen MS, Schleck CD and Pairolero PC: Chest-wall desmoid tumors: Results of surgical intervention. Ann Thorac Surg. 78:1219–1223. 2004. View Article : Google Scholar : PubMed/NCBI
5	Croce S, Letourneux C, Dale G and Mathelin C: Breast fibromatosis: An uncommon benign breast disease. Gynecol Obstet Fertil. 37:442–446. 2009. View Article : Google Scholar : PubMed/NCBI
6	Taylor TV and Sosa J: Bilateral breast fibromatosis: Case report and review of the literature. J Surg Educ. 68:320–325. 2011. View Article : Google Scholar : PubMed/NCBI
7	Yamaguchi H, Sakakibara T, Hino M, Ryu M, Senuma K, Nakai K, Tomiki Y, Sakamoto K, Kamano T, Tsurumaru M and Matsumoto T: A case of fibromatosis of the breast. Breast Cancer. 9:175–178. 2002. View Article : Google Scholar : PubMed/NCBI
8	Ha KY, Deleon P and Hamilton R: Breast fibromatosis mimicking breast carcinoma. Proc (Bayl Univ Med Cent). 26:pp. 22–24. 2013; PubMed/NCBI
9	He P, Cui LG, Lei YT, Liu JY and Wang JR: Ultrasound elastographic findings of mammary fibromatosis. Case Rep Radiol. 2015:8294682015.PubMed/NCBI
10	Plaza MJ and Yepes M: Breast fibromatosis response to tamoxifen: Dynamic MRI findings and review of the current treatment options. J Radiol Case Rep. 6:16–23. 2012.PubMed/NCBI
11	Matherne TH, Green A Jr, Tucker JA and Dyess DL: Fibromatosis: The breast cancer imitator. South Med J. 97:1100–1103. 2004. View Article : Google Scholar : PubMed/NCBI
12	Jeong WS, Oh TS, Sim HB and Eom JS: Desmoid tumor following augmentation mammoplasty with silicone implants. Arch Plast Surg. 40:470–472. 2013. View Article : Google Scholar : PubMed/NCBI
13	Hamada S, Futamura N, Ikuta K, Urakawa H, Kozawa E, Ishiguro N and Nishida Y: CTNNB1 S45F mutation predicts poor efficacy of meloxicam treatment for desmoid tumors: A pilot study. PLoS One. 9:e963912014. View Article : Google Scholar : PubMed/NCBI
14	Nieuwenhuis MH, Casparie M, Mathus-Vliegen LM, Dekkers OM, Hogendoorn PCW and Vasen HF: A nation-wide study comparing sporadicand familial adenomatous polyposis-related desmoid-type fibromatoses. Int J Cancer. 129:256–261. 2011. View Article : Google Scholar : PubMed/NCBI
15	Rakha EA, Badve S, Eusebi V, Reis-Filho JS, Fox SB, Dabbs DJ, Decker T, Hodi Z, Ichihara S, Lee AH, et al: Breast lesions of uncertain malignant nature and limited metastatic potential: Proposals to improve their recognition and clinical management. Histopathology. 68:45–56. 2016. View Article : Google Scholar : PubMed/NCBI
16	Kasper B, Baumgarten C, Bonvalot S, Haas R, Haller F, Hohenberger P, Moreau G, van der Graaf WT and Gronchi A; Desmoid Working Group, : Management of sporadic desmoid-type fibromatosis: a European consensus approach based on patients' and professionals' expertise-a sarcoma patients EuroNet and European Organisation for Research and Treatment of Cancer/Soft Tissue and Bone Sarcoma Group initiative. Eur J Cancer. 51:127–136. 2015. View Article : Google Scholar : PubMed/NCBI
17	Fiore M, Rimareix F, Mariani L, Domont J, Collini P, Le Péchoux C, Casali PG, Le Cesne A, Gronchi A and Bonvalot S: Desmoid-type fibromatosis: A front-line conservative approach to select patients for surgical treatment. Ann Surg Oncol. 16:2587–2593. 2009. View Article : Google Scholar : PubMed/NCBI
18	Bonvalot S, Ternès N, Fiore M, Bitsakou G, Colombo C, Honoré C, Marrari A, Le Cesne A, Perrone F, Dunant A and Gronchi A: Spontaneous regression of primary abdominal wall desmoid tumors: More common than previously thought. Ann Surg Oncol. 20:4096–4102. 2013. View Article : Google Scholar : PubMed/NCBI
19	Crago AM, Denton B, Salas S, Dufresne A, Mezhir JJ, Hameed M, Gonen M, Singer S and Brennan MF: A prognostic nomogram for prediction of recurrence in desmoid fibromatosis. Ann Surg. 258:347–353. 2013. View Article : Google Scholar : PubMed/NCBI
20	Keus RB, Nout RA, Blay JY, de Jong JM, Hennig I, Saran F, Hartmann JT, Sunyach MP, Gwyther SJ, Ouali M, et al: Results of a phase II pilot study of moderate dose radiotherapy for inoperable desmoid-type fibromatosis-an EORTC STBSG and ROG study (EORTC 62991–22998). Ann Oncol. 24:2672–2676. 2013. View Article : Google Scholar : PubMed/NCBI
21	Colombo C, Miceli R, Le Péchoux C, Palassini E, Honoré C, Stacchiotti S, Mir O, Casali PG, Dômont J, Fiore M, et al: Sporadic extra abdominal wall desmoid-type fibromatosis: Surgical resection can be safely limited to a minority of patients. Eur J Cancer. 51:186–192. 2015. View Article : Google Scholar : PubMed/NCBI
22	Al-Jazrawe M, Au M and Alman B: Optimal therapy for desmoid tumors: Current options and challenges for the future. Expert Rev Anticancer Ther. 15:1443–1458. 2015. View Article : Google Scholar : PubMed/NCBI