Open Access

High expression levels of Wnt5a and Ror2 in laryngeal squamous cell carcinoma are associated with poor prognosis

  • Authors:
    • Wei Zhang
    • Yongbing Yan
    • Miao Gu
    • Xudong Wang
    • Huijun Zhu
    • Shu Zhang
    • Wei Wang
  • View Affiliations

  • Published online on: June 15, 2017     https://doi.org/10.3892/ol.2017.6386
  • Pages: 2232-2238
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study investigated the prognostic significance of Wnt family member 5a (Wnt5a) and receptor tyrosine kinase‑like orphan receptor 2 (Ror2) expression in laryngeal squamous cell carcinoma (LSCC). The protein expression levels of Wnt5a and Ror2 were analyzed in specimens from 137 patients with LSCC, using immunohistochemical staining of tissue microarrays and pairs of LSCC and adjacent tissue samples, and examined the associations between the two markers and various clinicopathological parameters. The Wnt5a and Ror2 expression levels were significantly higher in LSCC tissues than in normal tissue samples (Wnt5a, P=0.015; Ror2, P=0.039), and were significantly associated with high tumor stage (P<0.001), lymph node metastasis (Wnt5a, P=0.029; Ror2, P=0.018), and with each other (P=0.002). Patients with LSCC with high Wnt5a or Ror2 expression had poorer prognosis compared with those with low Wnt5a (P=0.022) or Ror2 (P=0.038) expression. Thus, Wnt5a and Ror2 may affect LSCC development, and are potential biomarkers in LSCC.
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August-2017
Volume 14 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhang W, Yan Y, Gu M, Wang X, Zhu H, Zhang S and Wang W: High expression levels of Wnt5a and Ror2 in laryngeal squamous cell carcinoma are associated with poor prognosis. Oncol Lett 14: 2232-2238, 2017.
APA
Zhang, W., Yan, Y., Gu, M., Wang, X., Zhu, H., Zhang, S., & Wang, W. (2017). High expression levels of Wnt5a and Ror2 in laryngeal squamous cell carcinoma are associated with poor prognosis. Oncology Letters, 14, 2232-2238. https://doi.org/10.3892/ol.2017.6386
MLA
Zhang, W., Yan, Y., Gu, M., Wang, X., Zhu, H., Zhang, S., Wang, W."High expression levels of Wnt5a and Ror2 in laryngeal squamous cell carcinoma are associated with poor prognosis". Oncology Letters 14.2 (2017): 2232-2238.
Chicago
Zhang, W., Yan, Y., Gu, M., Wang, X., Zhu, H., Zhang, S., Wang, W."High expression levels of Wnt5a and Ror2 in laryngeal squamous cell carcinoma are associated with poor prognosis". Oncology Letters 14, no. 2 (2017): 2232-2238. https://doi.org/10.3892/ol.2017.6386