Open Access

Microbial infection, inflammation and epithelial ovarian cancer (Review)

  • Authors:
    • Xiaohui Xie
    • Mengyuan Yang
    • Yiling Ding
    • Jianlin Chen
  • View Affiliations

  • Published online on: June 15, 2017     https://doi.org/10.3892/ol.2017.6388
  • Pages: 1911-1919
  • Copyright: © Xie et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Ovarian cancer is the most common, and life‑threatening, type of female gynecological cancer. The etiology of ovarian cancer remains unclear, and there are currently no effective screening or treatment methods for the disease. Microbial infection serves a marked function in inducing carcinogenesis. A number of studies have identified pelvic inflammatory disease as a risk factor for epithelial ovarian cancer. Thus, it is hypothesized that microbial infection may contribute to ovarian cancer. In the present review, the microorganisms that have been identified to be associated with ovarian cancer and the underlying molecular mechanisms involved are discussed. Infection‑induced chronic inflammation is considered an important process for carcinogenesis, cancer progression and metastasis. Therefore, the pathological process and associated inflammatory factors are reviewed in the present paper.
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August-2017
Volume 14 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Xie X, Yang M, Ding Y and Chen J: Microbial infection, inflammation and epithelial ovarian cancer (Review). Oncol Lett 14: 1911-1919, 2017
APA
Xie, X., Yang, M., Ding, Y., & Chen, J. (2017). Microbial infection, inflammation and epithelial ovarian cancer (Review). Oncology Letters, 14, 1911-1919. https://doi.org/10.3892/ol.2017.6388
MLA
Xie, X., Yang, M., Ding, Y., Chen, J."Microbial infection, inflammation and epithelial ovarian cancer (Review)". Oncology Letters 14.2 (2017): 1911-1919.
Chicago
Xie, X., Yang, M., Ding, Y., Chen, J."Microbial infection, inflammation and epithelial ovarian cancer (Review)". Oncology Letters 14, no. 2 (2017): 1911-1919. https://doi.org/10.3892/ol.2017.6388