Open Access

Overexpression of cofilin correlates with poor survival in breast cancer: A tissue microarray analysis

  • Authors:
    • Yusufu Maimaiti
    • Jie Tan
    • Zeming Liu
    • Yawen Guo
    • Yu Yan
    • Xiu Nie
    • Bangxing Huang
    • Jing Zhou
    • Tao Huang
  • View Affiliations

  • Published online on: June 19, 2017     https://doi.org/10.3892/ol.2017.6413
  • Pages: 2288-2294
  • Copyright: © Maimaiti et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cofilin, a key regulator of actin cytoskeleton dynamics, is considered to be involved in cellular migration, tumor invasion and mitosis, and its activity is increased in cancer cells. To address the association between cofilin and breast cancer prognosis, which is unclear at present, cofilin expression was analyzed in tissue microarrays of tumors from 310 patients with breast cancer via immunohistochemistry. In a multivariate Cox regression analysis, a high expression of cofilin in tumor cells correlated significantly with shorter overall survival (hazard ratio, 2.22; 95% confidence interval, 1.35‑3.66, P=0.002, and with the Nottingham histologic grade, Ki‑67 status and human epidermal growth factor receptor 2 status (P=0.031, 0.001, and 0.001, respectively). Cofilin expression was not observed as correlated with estrogen or progesterone receptor expression, tumor size or lymph node status. These data demonstrate that cofilin is associated with poor outcome, thereby suggesting that it is a potential prognostic factor in breast cancer.
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August-2017
Volume 14 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Maimaiti Y, Tan J, Liu Z, Guo Y, Yan Y, Nie X, Huang B, Zhou J and Huang T: Overexpression of cofilin correlates with poor survival in breast cancer: A tissue microarray analysis. Oncol Lett 14: 2288-2294, 2017
APA
Maimaiti, Y., Tan, J., Liu, Z., Guo, Y., Yan, Y., Nie, X. ... Huang, T. (2017). Overexpression of cofilin correlates with poor survival in breast cancer: A tissue microarray analysis. Oncology Letters, 14, 2288-2294. https://doi.org/10.3892/ol.2017.6413
MLA
Maimaiti, Y., Tan, J., Liu, Z., Guo, Y., Yan, Y., Nie, X., Huang, B., Zhou, J., Huang, T."Overexpression of cofilin correlates with poor survival in breast cancer: A tissue microarray analysis". Oncology Letters 14.2 (2017): 2288-2294.
Chicago
Maimaiti, Y., Tan, J., Liu, Z., Guo, Y., Yan, Y., Nie, X., Huang, B., Zhou, J., Huang, T."Overexpression of cofilin correlates with poor survival in breast cancer: A tissue microarray analysis". Oncology Letters 14, no. 2 (2017): 2288-2294. https://doi.org/10.3892/ol.2017.6413