Open Access

Identification of the prognostic value of lymphocyte-to-monocyte ratio in patients with HBV-associated advanced hepatocellular carcinoma

  • Authors:
    • Ying‑Fen Hong
    • Zhan‑Hong Chen
    • Li Wei
    • Xiao‑Kun Ma
    • Xing Li
    • Jing‑Yun Wen
    • Tian‑Tian Wang
    • Xiu‑Rong Cai
    • Dong‑Hao Wu
    • Jie Chen
    • Dan‑Yun Ruan
    • Ze‑Xiao Lin
    • Qu Lin
    • Min Dong
    • Xiang‑Yuan Wu
  • View Affiliations

  • Published online on: June 19, 2017     https://doi.org/10.3892/ol.2017.6420
  • Pages: 2089-2096
  • Copyright: © Hong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The inflammatory microenvironment serves an important function in the progression of hepatocellular carcinoma (HCC). Peripheral blood lymphocyte-to-monocyte ratio (LMR), as a novel inflammatory biomarker combining an estimate of host immune homeostasis with the tumor microenvironment, has been identified to be a predictor of clinical outcomes in a number of malignancies. The present study aimed at investigating the prognostic value of LMR in patients with hepatitis B virus (HBV)-associated advanced HCC. A total of 174 patients with HBV‑associated advanced HCC, without fever or signs of infections, were analyzed. Clinicopathological parameters, including LMR, were eva­luated to identify predictors of overall survival time. Univariate and multivariate analysis was performed using Cox's proportional hazards model. A threshold value was determined using a time‑dependent receiver operating characteristic curve. Univariate and multivariate analysis identified LMR as an independent prognostic factor in overall survival (OS) time in patients with HBV‑associated advanced HCC (P<0.05). The threshold value of LMR was 2.22. All patients were divided into either a low LMR group (≤2.22) or a high LMR group (>2.22). The OS time of the high LMR group was significantly longer compared with the low LMR group (P<0.001). Patients in the high LMR group exhibited a significantly increased 3‑month and 6‑month OS rate, compared with that of the patients within the low LMR group (P<0.001). An increased level of LMR was significantly associated with the presence of metastasis, ascites and increased tumor size (P<0.01). LMR is an independent prognostic factor of HBV‑associated advanced HCC patients and an increased baseline LMR level indicates an improved prognosis.
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August-2017
Volume 14 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Hong YF, Chen ZH, Wei L, Ma XK, Li X, Wen JY, Wang TT, Cai XR, Wu DH, Chen J, Chen J, et al: Identification of the prognostic value of lymphocyte-to-monocyte ratio in patients with HBV-associated advanced hepatocellular carcinoma. Oncol Lett 14: 2089-2096, 2017.
APA
Hong, Y., Chen, Z., Wei, L., Ma, X., Li, X., Wen, J. ... Wu, X. (2017). Identification of the prognostic value of lymphocyte-to-monocyte ratio in patients with HBV-associated advanced hepatocellular carcinoma. Oncology Letters, 14, 2089-2096. https://doi.org/10.3892/ol.2017.6420
MLA
Hong, Y., Chen, Z., Wei, L., Ma, X., Li, X., Wen, J., Wang, T., Cai, X., Wu, D., Chen, J., Ruan, D., Lin, Z., Lin, Q., Dong, M., Wu, X."Identification of the prognostic value of lymphocyte-to-monocyte ratio in patients with HBV-associated advanced hepatocellular carcinoma". Oncology Letters 14.2 (2017): 2089-2096.
Chicago
Hong, Y., Chen, Z., Wei, L., Ma, X., Li, X., Wen, J., Wang, T., Cai, X., Wu, D., Chen, J., Ruan, D., Lin, Z., Lin, Q., Dong, M., Wu, X."Identification of the prognostic value of lymphocyte-to-monocyte ratio in patients with HBV-associated advanced hepatocellular carcinoma". Oncology Letters 14, no. 2 (2017): 2089-2096. https://doi.org/10.3892/ol.2017.6420