Open Access

Antitumoral effect of Ocoxin in hepatocellular carcinoma

  • Authors:
    • Elena Díaz‑Rodríguez
    • Al‑Mahy El‑Mallah
    • Eduardo Sanz
    • Atanasio Pandiella
  • View Affiliations

  • Published online on: June 21, 2017     https://doi.org/10.3892/ol.2017.6440
  • Pages: 1950-1958
  • Copyright: © Díaz‑Rodríguez et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Hepatocellular carcinoma (HCC) is becoming one of the most prevalent types of cancer worldwide. The most efficient types of treatment at present include surgical resection and liver transplantation, but these treatments may only be used in a small percentage of patients. In order to identify novel therapeutic strategies for this disease, the present study explored the potential antitumoral effect of Ocoxin® oral solution (OOS) in HCC. OOS inhibited the proliferation of HCC cell lines in a time‑ and dose‑dependent manner, being more efficient when used in combination with sorafenib, a standard of care treatment for patients diagnosed with advanced‑stage disease. Mechanistic studies indicated that the effect of OOS was due to the induction of cell cycle arrest rather than the stimulation of apoptotic cell death. The cell cycle was slowed down in all phases in the HCC cell lines treated with OOS. Finally, when tested in animal models of HCC, OOS reduced tumor progression through the induction of necrosis in xenograft tumor models. Considering the poor prognosis and high resistance to antitumor treatments of HCC, the antiproliferative action of OOS, particularly in combination with sorafenib, provides the opportunity to investigate the effect of combined therapy in a clinical setting.
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August-2017
Volume 14 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Díaz‑Rodríguez E, El‑Mallah AM, Sanz E and Pandiella A: Antitumoral effect of Ocoxin in hepatocellular carcinoma. Oncol Lett 14: 1950-1958, 2017
APA
Díaz‑Rodríguez, E., El‑Mallah, A., Sanz, E., & Pandiella, A. (2017). Antitumoral effect of Ocoxin in hepatocellular carcinoma. Oncology Letters, 14, 1950-1958. https://doi.org/10.3892/ol.2017.6440
MLA
Díaz‑Rodríguez, E., El‑Mallah, A., Sanz, E., Pandiella, A."Antitumoral effect of Ocoxin in hepatocellular carcinoma". Oncology Letters 14.2 (2017): 1950-1958.
Chicago
Díaz‑Rodríguez, E., El‑Mallah, A., Sanz, E., Pandiella, A."Antitumoral effect of Ocoxin in hepatocellular carcinoma". Oncology Letters 14, no. 2 (2017): 1950-1958. https://doi.org/10.3892/ol.2017.6440