Utility of percutaneous radiofrequency ablation alone or combined with transarterial chemoembolization for early hepatocellular carcinoma

  • Authors:
    • Tsutomu Tamai
    • Akihiko Oshige
    • Kazuaki Tabu
    • Eriko Tabu
    • Syo Ijyuin
    • Haruka Sakae
    • Hiroka Onishi
    • Kaori Muromachi
    • Akiko Saisyoji
    • Kohei Oda
    • Kotaro Kumagai
    • Seiichi Mawatari
    • Akihiro Moriuchi
    • Kazuhiro Sakurai
    • Tsuyoshi Hori
    • Akio Ido
  • View Affiliations

  • Published online on: June 23, 2017     https://doi.org/10.3892/ol.2017.6476
  • Pages: 3199-3206
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Percutaneous radiofrequency ablation (RFA) combined with transarterial chemoembolization (TACE) is an effective, standard therapy against small hepatocellular carcinoma (HCC). However, there is debate regarding the effectiveness of RFA combined with TACE (RFA/TACE) compared with RFA alone. These two approaches were compared for the treatment of early HCC. The present study examined 83 HCC tumors in 83 patients treated with RFA between April 2007 and August 2014 at three medical institutions. All HCCs were single hypervascular tumors, with a median diameter of 16 mm (range, 6‑30 mm). The overall survival (OS) rate of all patients (n=83) was 97.5% at 1 year, 82.8% at 3 years and 48.6% at 5 years, and the local recurrence rate of all patients was 14.3% at 1 year, 32.3% at 3 years and 36.5% at 5 years. The tumor‑free survival (TFS) rate of all patients was 95.1% at 1 year, 56.3% at 3 years and 23.4% at 5 years. Compared with RFA alone, RFA/TACE significantly improved OS (P<0.001), intrahepatic distant recurrence (IDR; P=0.038) and TFS (P=0.010). A univariate analysis of prognostic indicators revealed that age <70 years (P=0.008), aspartate transaminase <40 IU/l (P=0.003), alanine aminotransferase <40 IU/l (P=0.006) and platelet count >10x104/µl (P=0.05) were associated with a high survival rate. Multivariate analysis identified RFA/TACE [hazard ratio (HR), 0.108; P=0.001] as an independent prognostic indicator. RFA/TACE was identified as the only independent indicator of IDR (HR: 0.467; P=0.042) and TFS (HR: 0.452; P=0.012). RFA/TACE improved OS rate, IDR and TFS compared with RFA alone. The data suggested that RFA/TACE should be considered for the treatment of single hypervascular HCC.
View Figures
View References

Related Articles

Journal Cover

September-2017
Volume 14 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Tamai T, Oshige A, Tabu K, Tabu E, Ijyuin S, Sakae H, Onishi H, Muromachi K, Saisyoji A, Oda K, Oda K, et al: Utility of percutaneous radiofrequency ablation alone or combined with transarterial chemoembolization for early hepatocellular carcinoma. Oncol Lett 14: 3199-3206, 2017.
APA
Tamai, T., Oshige, A., Tabu, K., Tabu, E., Ijyuin, S., Sakae, H. ... Ido, A. (2017). Utility of percutaneous radiofrequency ablation alone or combined with transarterial chemoembolization for early hepatocellular carcinoma. Oncology Letters, 14, 3199-3206. https://doi.org/10.3892/ol.2017.6476
MLA
Tamai, T., Oshige, A., Tabu, K., Tabu, E., Ijyuin, S., Sakae, H., Onishi, H., Muromachi, K., Saisyoji, A., Oda, K., Kumagai, K., Mawatari, S., Moriuchi, A., Sakurai, K., Hori, T., Ido, A."Utility of percutaneous radiofrequency ablation alone or combined with transarterial chemoembolization for early hepatocellular carcinoma". Oncology Letters 14.3 (2017): 3199-3206.
Chicago
Tamai, T., Oshige, A., Tabu, K., Tabu, E., Ijyuin, S., Sakae, H., Onishi, H., Muromachi, K., Saisyoji, A., Oda, K., Kumagai, K., Mawatari, S., Moriuchi, A., Sakurai, K., Hori, T., Ido, A."Utility of percutaneous radiofrequency ablation alone or combined with transarterial chemoembolization for early hepatocellular carcinoma". Oncology Letters 14, no. 3 (2017): 3199-3206. https://doi.org/10.3892/ol.2017.6476