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Primary lymphoepithelioma‑like carcinoma of the lung: An unusual cancer and clinical outcomes of 14 patients

  • Authors:
    • Lan Lin
    • Tingyan Lin
    • Bangwei Zeng

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  • Published online on: June 30, 2017     https://doi.org/10.3892/ol.2017.6510
  • Pages: 3110-3116
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Abstract

Advanced lung cancer is considered to exhibit a poor prognosis; however, the pulmonary lymphoepithelioma‑like carcinoma (LELC), a rare subtype of non‑small cell lung cancer (NSCLC), exhibits an improved prognosis, compared with non‑LELC. The present study aimed at investigating the clinical manifestation, imaging characteristics, pathology, tumor markers, treatment and prognosis of primary LELC of the lung. A total of 14 patients with pulmonary LELC were confirmed by surgery and pathology. Clinical data of those patients were retrospectively reviewed including age, sex, smoking history, symptoms, computed tomography (CT) results, Epstein‑Barr virus‑encoded RNA (EBER) status, treatment and outcomes. In the present study, there were 7 males and 7 females who ranged in age between 22 and 64 years (mean, 51.21±11.37 years) and who all were from eastern China. The tumor‑node‑metastasis stage ranged between stages I and IV, with 71.43% of the patients at advanced stage (stages III and IV). The results of the present study identified 100% positive expression of EBER. Tumors located centrally were of significantly increased size, compared with peripheral tumors (P<0.05), and lymphadenopathy was more common in patients with advanced stage (P<0.05). The majority of patients were treated with surgery, platinum‑based chemotherapy or radiotherapy. At time of writing, 12 patients were alive and the longest survival time was 60 months. Pulmonary LELC typically affected young patients and was not associated with smoking history; however, pulmonary LELC was associated with Epstein‑Barr virus infection in the Asian population. The majority of patients were in early or locally advanced stages and exhibit an improved prognosis compared with other types of NSCLC. Pulmonary LELC was sensitive to chemotherapy and surgery, with postoperative chemotherapy‑based multimodality treatment recommended.
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September-2017
Volume 14 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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  • CiteScore: 6.3
  • CiteScore Rank: Q2: #119/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.725
  • SCImago Journal Rank (SJR): 0.639
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Spandidos Publications style
Lin L, Lin T and Zeng B: Primary lymphoepithelioma‑like carcinoma of the lung: An unusual cancer and clinical outcomes of 14 patients. Oncol Lett 14: 3110-3116, 2017
APA
Lin, L., Lin, T., & Zeng, B. (2017). Primary lymphoepithelioma‑like carcinoma of the lung: An unusual cancer and clinical outcomes of 14 patients. Oncology Letters, 14, 3110-3116. https://doi.org/10.3892/ol.2017.6510
MLA
Lin, L., Lin, T., Zeng, B."Primary lymphoepithelioma‑like carcinoma of the lung: An unusual cancer and clinical outcomes of 14 patients". Oncology Letters 14.3 (2017): 3110-3116.
Chicago
Lin, L., Lin, T., Zeng, B."Primary lymphoepithelioma‑like carcinoma of the lung: An unusual cancer and clinical outcomes of 14 patients". Oncology Letters 14, no. 3 (2017): 3110-3116. https://doi.org/10.3892/ol.2017.6510