Open Access

Prognostic significance of the epithelial‑mesenchymal transition factor zinc finger E‑box‑binding homeobox 2 in esophageal squamous cell carcinoma

  • Authors:
    • Xiaodong Huo
    • Bin Huo
    • Huixing Wang
    • Hongdian Zhang
    • Zhao Ma
    • Mingjian Yang
    • Haitao Wang
    • Zhentao Yu
  • View Affiliations

  • Published online on: July 8, 2017     https://doi.org/10.3892/ol.2017.6559
  • Pages: 2683-2690
  • Copyright: © Huo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Zinc finger E‑box‑binding homeobox 2 (ZEB2) has been reported to mediate epithelial‑mesenchymal transition (EMT) and disease progression in several cancer types. However, the expression of ZEB2 in esophageal squamous cell carcinoma (OSCC) and its association with prognosis remains unclear. In the present study, a tissue microarray and immunohistochemistry were used to investigate ZEB2 and epithelial (E‑)cadherin expression in OSCC tissues (n=218) and peritumoral esophageal tissues (POT; n=60). There was a significantly increased incidence of positive ZEB2 expression in OSCC tissues compared with the expression in POTs (P<0.012). By contrast, the incidence of positive E‑cadherin expression in OSCC tissues was significantly decreased compared with the expression in POTs (P<0.004). ZEB2 expression in OSCC was associated with a number of clinicopathological factors, and it was also an independent predictive factor for shorter overall survival time (P<0.001). Overall, ZEB2 may promote OSCC metastasis and is a potential prognostic marker for malignancy.
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September-2017
Volume 14 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Huo X, Huo B, Wang H, Zhang H, Ma Z, Yang M, Wang H and Yu Z: Prognostic significance of the epithelial‑mesenchymal transition factor zinc finger E‑box‑binding homeobox 2 in esophageal squamous cell carcinoma. Oncol Lett 14: 2683-2690, 2017.
APA
Huo, X., Huo, B., Wang, H., Zhang, H., Ma, Z., Yang, M. ... Yu, Z. (2017). Prognostic significance of the epithelial‑mesenchymal transition factor zinc finger E‑box‑binding homeobox 2 in esophageal squamous cell carcinoma. Oncology Letters, 14, 2683-2690. https://doi.org/10.3892/ol.2017.6559
MLA
Huo, X., Huo, B., Wang, H., Zhang, H., Ma, Z., Yang, M., Wang, H., Yu, Z."Prognostic significance of the epithelial‑mesenchymal transition factor zinc finger E‑box‑binding homeobox 2 in esophageal squamous cell carcinoma". Oncology Letters 14.3 (2017): 2683-2690.
Chicago
Huo, X., Huo, B., Wang, H., Zhang, H., Ma, Z., Yang, M., Wang, H., Yu, Z."Prognostic significance of the epithelial‑mesenchymal transition factor zinc finger E‑box‑binding homeobox 2 in esophageal squamous cell carcinoma". Oncology Letters 14, no. 3 (2017): 2683-2690. https://doi.org/10.3892/ol.2017.6559