MicroRNA‑552 promotes tumor cell proliferation and migration by directly targeting DACH1 via the Wnt/β‑catenin signaling pathway in colorectal cancer

Cao,Jia; Yan,Xiu‑Rui; Liu,Ting; Han,Xue‑Bo; Yu,Jing‑Jing; Liu,Shi‑Hai; Wang,Li‑Bin

doi:10.3892/ol.2017.6600

MicroRNA‑552 promotes tumor cell proliferation and migration by directly targeting DACH1 via the Wnt/β‑catenin signaling pathway in colorectal cancer

Authors:
- Jia Cao
- Xiu‑Rui Yan
- Ting Liu
- Xue‑Bo Han
- Jing‑Jing Yu
- Shi‑Hai Liu
- Li‑Bin Wang
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Affiliations: Department of Medical Laboratory, Ningxia Medical University, Clinical Medicine College, Yinchuan, Ningxia 750004, P.R. China, Stem Cell Institute, The General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China, Central Laboratory, The Affiliated Hospital of Qingdao University, Animal Experimental Center, Qingdao, Shandong 266003, P.R. China
Published online on: July 18, 2017 https://doi.org/10.3892/ol.2017.6600
Pages: 3795-3802

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Abstract

The purpose of the present study was to analyze the crucial role of microRNAs (miRNAs/miRs) involved in the proliferation and migration of colorectal cancer (CRC) and to investigate their underlying mechanisms. The present study discusses the expression and function of miR‑552 in CRC. The expression level of miR‑552 in CRC cells and tissues was observed, and it was suggested that the high expression of miR‑552 accelerated the proliferation and migration of CRC cells in vitro. Notably, a result of the present study was that the cell fate determination factor Dachshund family transcription factor 1 (DACH1) was identified as a direct target of miR‑552. Suppressing miR‑552 expression in CRC cells increased endogenous DACH1 mRNA and protein levels, which was negatively correlated with miR‑552. DACH1 performs an important role in the development of a number of neoplasms, and has the ability to regulate the Wnt/β‑catenin signaling pathway as a novel predictive and diagnostic biomarker. Accordingly, it was concluded that miR‑552 exerted a tumor‑promoting role in CRC development by targeting DACH1, which may contribute to the increase in the rates of CRC proliferation and migration. miR‑552 may serve as a potential diagnostic and prognostic biomarker for CRC.

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