search button

Vascular endothelial growth factor and protein level in pleural effusion for differentiating malignant from benign pleural effusion

  • Authors:
    • Da‑Wei Wu
    • Wei‑An Chang
    • Kuan‑Ting Liu
    • Meng‑Chi Yen
    • Po‑Lin Kuo

  • View Affiliations

  • Published online on: July 20, 2017     https://doi.org/10.3892/ol.2017.6631
  • Pages: 3657-3662
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Pleural effusion is associated with multiple benign and malignant conditions. Currently no biomarkers differentiate malignant pleural effusion (MPE) and benign pleural effusion (BPE) sensitively and specifically. The present study identified a novel combination of biomarkers in pleural effusion for differentiating MPE from BPE by enrolling 75 patients, 34 with BPE and 41 with MPE. The levels of lactate dehydrogenase, glucose, protein, and total cell, neutrophil, monocyte and lymphocyte counts in the pleural effusion were measured. The concentrations of interleukin (IL)‑1β, IL‑4, IL‑5, IL‑6, IL‑8, IL‑10, IL‑12, tumor necrosis factor‑α, interferon γ, transforming growth factor‑β1, colony stimulating factor 2, monocyte chemoattractant protein‑1 and vascular endothelial growth factor (VEGF) were detected using cytometric bead arrays. Protein and VEGF levels differed significantly between patients with BPE and those with MPE. The optimal cutoff value of VEGF and protein was 214 pg/ml and 3.35 g/dl respectively, according to the receiver operating characteristic curve. A combination of VEGF >214 pg/ml and protein >3.35 g/dl in pleural effusion presented a sensitivity of 92.6% and an accuracy of 78.6% for MPE, but was not associated with a decreased survival rate. These results suggested that this novel combination strategy may provide useful biomarkers for predicting MPE and facilitating early diagnosis.
View Figures
View References

Related Articles

Journal Cover

September-2017
Volume 14 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

  • Journal Metrics
  • Impact Factor: 2.5
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 5.7
  • CiteScore Rank: Q2: #139/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.574
  • SCImago Journal Rank (SJR): 0.644
International Symposium on Molecular Medicine Conference Banner
The Cancer Story
World Congress on Advances in Oncology and International Symposium on Molecular Medicine Conference Banner
World Academy Of Sciences Banner
Heyday Road Banner

0

Copy and paste a formatted citation
x
Spandidos Publications style
Wu DW, Chang WA, Liu KT, Yen MC and Kuo PL: Vascular endothelial growth factor and protein level in pleural effusion for differentiating malignant from benign pleural effusion. Oncol Lett 14: 3657-3662, 2017.
APA
Wu, D., Chang, W., Liu, K., Yen, M., & Kuo, P. (2017). Vascular endothelial growth factor and protein level in pleural effusion for differentiating malignant from benign pleural effusion. Oncology Letters, 14, 3657-3662. https://doi.org/10.3892/ol.2017.6631
MLA
Wu, D., Chang, W., Liu, K., Yen, M., Kuo, P."Vascular endothelial growth factor and protein level in pleural effusion for differentiating malignant from benign pleural effusion". Oncology Letters 14.3 (2017): 3657-3662.
Chicago
Wu, D., Chang, W., Liu, K., Yen, M., Kuo, P."Vascular endothelial growth factor and protein level in pleural effusion for differentiating malignant from benign pleural effusion". Oncology Letters 14, no. 3 (2017): 3657-3662. https://doi.org/10.3892/ol.2017.6631