Hepatectomy for spontaneous rupture of hepatocellular carcinoma without portal triad clamping

Wang,Zhi‑Ming; Lu,Xin‑Sheng; Qiu,Fu

doi:10.3892/ol.2017.6654

Hepatectomy for spontaneous rupture of hepatocellular carcinoma without portal triad clamping

Authors:
- Zhi‑Ming Wang
- Xin‑Sheng Lu
- Fu Qiu
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Affiliations: Department of General Surgery, Xiangya Hospital, Central South University, Changsha 410008, P.R. China, Department of General Surgery, Xiangya Third Hospital, Central South University, Changsha 410013, P.R. China
Published online on: July 24, 2017 https://doi.org/10.3892/ol.2017.6654
Pages: 3997-4004
Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Hepatectomy without portal triad clamping may decrease the incidence of liver injury; however, the effects of hepatectomy without portal triad clamping in the treatment of spontaneous rupture of hepatocellular carcinoma (SRHCC) remain unclear. The aims of the present study were to evaluate the therapeutic value of hepatectomy without portal triad clamping in the treatment of patients with SRHCC. The present study retrospectively reviewed patients with SRHCC who received hepatectomy without portal triad clamping (non‑clamping group) and the therapeutic efficacy was compared with that of 20 patients with SRHCC undergoing the same surgery in the presence of portal triad clamping (clamping group). Following hepatectomy, the non‑clamping group exhibited a significantly lower incidence of acute liver failure compared with the clamping group (P<0.05). No significant differences in operative time, intra‑operative blood loss, disease‑free or overall survival times between the two groups were identified (all P>0.05). At 1 week and 2 weeks after surgery, the non‑clamping group exhibited significantly lower alanine aminotransferase, aspartate aminotransferase and total bilirubin serum levels compared with the clamping group (all P<0.05). Hepatectomy without portal triad clamping may decrease the incidence of liver injury and liver failure in patients with SRHCC, suggesting that it may be a safe and effective therapeutic strategy.

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1	Yeh CN, Lee WC, Jeng LB, Chen MF and Yu MC: Spontaneous tumour rupture and prognosis in patients with hepatocellular carcinoma. Br J Surg. 89:1125–1129. 2002. View Article : Google Scholar : PubMed/NCBI
2	Kim PT, Su JC, Buczkowski AK, Schaeffer DF, Chung SW, Scudamore CH and Ho SG: Computed tomography and angiographic interventional features of ruptured hepatocellular carcinoma: Pictorial essay. Can Assoc Radiol J. 57:159–168. 2006.PubMed/NCBI
3	Lee WM, Stravitz RT and Larson AM: Introduction to the revised American association for the study of liver diseases position paper on acute liver failure, 2011. Hepatology. 55:965–967. 2012. View Article : Google Scholar : PubMed/NCBI
4	Lü XS, Zheng YS and Fan QQ: Liver resection for spontaneous rupture of primary hepatocellular carcinoma. The Chinese-German Journal of Clinical Oncology. 2:23–24. 2003. View Article : Google Scholar
5	Battula N, Madanur M, Priest O, Srinivasan P, O'Grady J, Heneghan MA, Bowles M, Muiesan P, Heaton N and Rela M: Spontaneous rupture of hepatocellular carcinoma: A western experience. Am J Surg. 197:164–167. 2009. View Article : Google Scholar : PubMed/NCBI
6	Bulger EM, May S, Kerby JD, Emerson S, Stiell IG, Schreiber MA, Brasel KJ, Tisherman SA, Coimbra R, Rizoli S, et al: Out-of-hospital hypertonic resuscitation after traumatic hypovolemic shock: A randomized, placebo controlled trial. Ann Surg. 253:431–441. 2011. View Article : Google Scholar : PubMed/NCBI
7	Zhang J, Ye L, Zhang J, Lin M, He S, Mao X, Zhou X and Zhi F: MELD scores and Child-Pugh classifications predict the outcomes of ERCP in cirrhotic patients with choledocholithiasis: A retrospective cohort study. Medicine (Baltimore). 94:e4332015. View Article : Google Scholar : PubMed/NCBI
8	Ngan H, Tso WK, Lai CL and Fan ST: The role of hepatic arterial embolization in the treatment of spontaneous rupture of hepatocellular carcinoma. Clin Radiol. 53:338–341. 1998. View Article : Google Scholar : PubMed/NCBI
9	Kim JY, Lee JS, Oh DH, Yim YH and Lee HK: Transcatheter arterial chemoembolization confers survival benefit in patients with a spontaneously ruptured hepatocellular carcinoma. Eur J Gastroenterol Hepatol. 24:640–645. 2012. View Article : Google Scholar : PubMed/NCBI
10	Hsueh KC, Fan HL, Chen TW, Chan DC, Yu JC, Tsou SS, Chang TM and Hsieh CB: Management of spontaneously ruptured hepatocellular carcinoma and hemoperitoneum manifested as acute abdomen in the emergency room. World J Surg. 36:2670–2676. 2012. View Article : Google Scholar : PubMed/NCBI
11	Andersson R, Tranberg KG and Bengmark S: Hemoperitoneum after spontaneous rupture of liver tumor: Results of surgical treatment. HPB Surg. 1:81–83. 1988. View Article : Google Scholar : PubMed/NCBI
12	Shirabe K, Kitamura M, Tsutsui S, Maeda T, Matsumata T and Sugimachi K: A long-term survivor of ruptured hepatocellular carcinoma after hepatic resection. J Gastroenterol Hepatol. 10:351–354. 1995. View Article : Google Scholar : PubMed/NCBI
13	Chen ZY, Qi QH and Dong ZL: Etiology and management of hemorrhage in spontaneous liver rupture: A report of 70 cases. World J Gastroenterol. 8:1063–1066. 2002. View Article : Google Scholar : PubMed/NCBI
14	Marini P, Vilgrain V and Belghiti J: Management of spontaneous rupture of liver tumours. Dig Surg. 19:109–113. 2002. View Article : Google Scholar : PubMed/NCBI
15	Leung CS, Tang CN, Fung KH and Li MK: A retrospective review of transcatheter hepatic arterial embolisation for ruptured hepatocellular carcinoma. J R Coll Surg Edinb. 47:685–688. 2002.PubMed/NCBI
16	Tanaka A, Takeda R, Mukaihara S, Hayakawa K, Shibata T, Itoh K, Nishida N, Nakao K, Fukuda Y, Chiba T and Yamaoka Y: Treatment of ruptured hepatocellular carcinoma. Int J Clin Oncol. 6:291–295. 2001. View Article : Google Scholar : PubMed/NCBI
17	Lee HS, Choi GH, Kang DR, Han KH, Ahn SH, Kim DY, Park JY, Kim SU and Choi JS: Impact of spontaneous hepatocellular carcinoma rupture on recurrence pattern and long-term surgical outcomes after partial hepatectomy. World J Surg. 38:2070–2078. 2014. View Article : Google Scholar : PubMed/NCBI
18	Sonoda T, Kanematsu T, Takenaka K and Sugimachi K: Ruptured hepatocellular carcinoma evokes risk of implanted metastases. J Surg Oncol. 41:183–186. 1989. View Article : Google Scholar : PubMed/NCBI
19	Okano J, Shiota G, Horie Y, Mitsuda A, Suou T, Kawasaki H and Oofuji S: Rupture of metastatic nodule on the peritoneal surface secondary to hepatocellular carcinoma. Intern Med. 35:783–784. 1996. View Article : Google Scholar : PubMed/NCBI
20	Yunoki Y, Takeuchi H, Makino Y, Murakami I, Yasui Y, Tanakaya K, Kawaguchi K and Konaga E: Intraperitoneal seeding of ruptured hepatocellular carcinoma: Case report. Abdom Imaging. 24:398–400. 1999. View Article : Google Scholar : PubMed/NCBI
21	Eriguchi N, Aoyagi S, Okuda K, Tamae T, Fukuda S, Kanazawa N, Hamada S, Kawabata M, Nishimura K and Kodama T: Successful surgical treatment for implanted intraperitoneal metastases of hepatocellular carcinoma. J Hepatobiliary Pancreat Surg. 7:520–523. 2000. View Article : Google Scholar : PubMed/NCBI
22	Lin CC, Chen CH, Tsang YM, Jan IS and Sheu JC: Diffuse intraperitoneal metastasis after spontaneous rupture of hepatocellular carcinoma. J Formos Med Assoc. 105:577–582. 2006. View Article : Google Scholar : PubMed/NCBI
23	Chang YM, Hsu KF, Yu JC, Chan DC, Chen CJ, Chen TW, Hsieh CB and Hsieh HF: Distilled water peritoneal lavage in patients with rupture hepatocellular carcinoma. Hepatogastroenterology. 60:140–143. 2013.PubMed/NCBI
24	Yang T, Sun YF, Zhang J, Lau WY, Lai EC, Lu JH, Shen F and Wu MC: Partial hepatectomy for ruptured hepatocellular carcinoma. Br J Surg. 100:1071–1079. 2013. View Article : Google Scholar : PubMed/NCBI
25	Qian NS, Liao YH, Cai SW, Raut V and Dong JH: Comprehensive application of modern technologies in precise liver resection. Hepatobiliary Pancreat Dis Int. 12:244–250. 2013. View Article : Google Scholar : PubMed/NCBI
26	Tashiro H, Kuroda S, Mikuriya Y and Ohdan H: Ischemia-reperfusion injury in patients with fatty liver and the clinical impact of steatotic liver on hepatic surgery. Surg Today. 44:1611–1625. 2014. View Article : Google Scholar : PubMed/NCBI
27	Ramakrishna G, Rastogi A, Trehanpati N, Sen B, Khosla R and Sarin SK: From cirrhosis to hepatocellular carcinoma: New molecular insights on inflammation and cellular senescence. Liver Cancer. 2:367–383. 2013. View Article : Google Scholar : PubMed/NCBI
28	Wrightson WR, Edwards MJ and McMasters KM: The role of the ultrasonically activated shears and vascular cutting stapler in hepatic resection. Am Surg. 66:1037–1040. 2000.PubMed/NCBI
29	Zhu Q, Li J, Yan JJ, Huang L, Wu MC and Yan YQ: Predictors and clinical outcomes for spontaneous rupture of hepatocellular carcinoma. World J Gastroenterol. 18:7302–7307. 2012. View Article : Google Scholar : PubMed/NCBI