Prognostic value of combined platelet, fibrinogen, neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in patients with lung adenosquamous cancer

  • Authors:
    • Yu‑Qian Wang
    • Qiong‑Jie Zhi
    • Xin‑Yue Wang
    • Dong‑Sheng Yue
    • Kai Li
    • Ri‑Cheng Jiang
  • View Affiliations

  • Published online on: July 24, 2017     https://doi.org/10.3892/ol.2017.6660
  • Pages: 4331-4338
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Abstract

The aim of the present study was to investigate the prognostic value of the combined platelet (PLT), fibrinogen (FBG), neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) (CO‑NPF) for postoperative outcomes in patients with lung adenosquamous cancer (ASC). Test results from patients who presented at The Cancer Institute and Hospital of Tianjin Medical University between January 2005 and December 2013 were retrospectively reviewed. CO‑NPF was scored between 0 and 4 according to increased PLT, FBG, NLR and PLR prior to being split into two groups based on the presence (≥2) or absence (<2) of the combination of increased inflammatory indexes. In total, data from 134 patients with ASC were reviewed for the present study. Multivariate analysis identified that increased CO‑NPF (P=0.001 and P<0.001, respectively), PLR (P=0.011 and P=0.001, respectively) and FBG (P=0.001 and P<0.001, respectively) were independently associated with shorter disease‑free survival (DFS) and overall survival (OS). NLR (P=0.006) and PLT (P=0.001) were independent prognostic factors for OS. The area under the receiver operating characteristic curves of CO‑NPF (area under the curve, 0.652, P=0.008, 95% confidence interval, 0.551‑0.752) was increased compared with NLR, PLR, PLT and FBG individually, suggesting that CO‑NPF has greater predictive value. CO‑NPF was significantly and independently associated with shorter DFS and OS, and had greater predictive value compared with NLR, PLR, PLT and FBG in patients with ASC who underwent surgery.
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October-2017
Volume 14 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Wang YQ, Zhi QJ, Wang XY, Yue DS, Li K and Jiang RC: Prognostic value of combined platelet, fibrinogen, neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in patients with lung adenosquamous cancer. Oncol Lett 14: 4331-4338, 2017.
APA
Wang, Y., Zhi, Q., Wang, X., Yue, D., Li, K., & Jiang, R. (2017). Prognostic value of combined platelet, fibrinogen, neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in patients with lung adenosquamous cancer. Oncology Letters, 14, 4331-4338. https://doi.org/10.3892/ol.2017.6660
MLA
Wang, Y., Zhi, Q., Wang, X., Yue, D., Li, K., Jiang, R."Prognostic value of combined platelet, fibrinogen, neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in patients with lung adenosquamous cancer". Oncology Letters 14.4 (2017): 4331-4338.
Chicago
Wang, Y., Zhi, Q., Wang, X., Yue, D., Li, K., Jiang, R."Prognostic value of combined platelet, fibrinogen, neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in patients with lung adenosquamous cancer". Oncology Letters 14, no. 4 (2017): 4331-4338. https://doi.org/10.3892/ol.2017.6660