Potential use of microRNA‑200c as a prognostic marker in non‑small cell lung cancer

  • Authors:
    • Libo Si
    • Hui Tian
    • Weiming Yue
    • Lin Li
    • Shuhai Li
    • Cun Gao
    • Lei Qi
  • View Affiliations

  • Published online on: July 25, 2017     https://doi.org/10.3892/ol.2017.6667
  • Pages: 4325-4330
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

MicroRNAs (miRNAs/miRs) are a class of small, highly conserved non‑coding RNAs that can serve either oncogenic or tumor‑suppressive roles in a wide variety of tumors. miR‑200c is a member of the miR‑200 family whose specific role in non‑small cell lung cancer (NSCLC) has not yet been elucidated. The purpose of the present study was to detect the expression level of miR‑200c in NSCLC, and to analyze its association with clinicopathological factors and patient prognosis. The present study determined the expression levels of miR‑200c in 110 tumor samples collected from patients diagnosed with NSCLC who underwent complete tumor resection with regional lymph node dissection, as assessed by reverse transcription‑quantitative polymerase chain reaction. The association between the expression level of miR‑200c and clinicopathological features and patient prognosis was also analyzed. The results showed that miR‑200c overexpression was detected in 66 of the 110 cases and was significantly associated with positive lymph node metastasis (P<0.001). Univariate survival analysis demonstrated that high miR‑200c expression, positive lymph node metastasis and advanced Tumor‑Node‑Metastasis (TNM) classification stage significantly predicted decreased 5‑year disease‑free survival rates (all P<0.05) and poor 5‑year overall survival rates (all P<0.01), respectively. The results of multivariate Cox regression analysis showed that TNM stage and miR‑200c expression retained its significance as an independent prognostic factor for unfavorable 5‑year disease‑free survival rates (P<0.05) and poor 5‑year overall survival rates (P<0.01). The present findings suggest that miR‑200c overexpression is significantly associated with poor survival rates in NSCLC and that miR‑200c could play an oncogenic role. miR‑200c may have clinical potential as a promising prognostic predictor for patients with NSCLC.
View Figures
View References

Related Articles

Journal Cover

October-2017
Volume 14 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Si L, Tian H, Yue W, Li L, Li S, Gao C and Qi L: Potential use of microRNA‑200c as a prognostic marker in non‑small cell lung cancer. Oncol Lett 14: 4325-4330, 2017
APA
Si, L., Tian, H., Yue, W., Li, L., Li, S., Gao, C., & Qi, L. (2017). Potential use of microRNA‑200c as a prognostic marker in non‑small cell lung cancer. Oncology Letters, 14, 4325-4330. https://doi.org/10.3892/ol.2017.6667
MLA
Si, L., Tian, H., Yue, W., Li, L., Li, S., Gao, C., Qi, L."Potential use of microRNA‑200c as a prognostic marker in non‑small cell lung cancer". Oncology Letters 14.4 (2017): 4325-4330.
Chicago
Si, L., Tian, H., Yue, W., Li, L., Li, S., Gao, C., Qi, L."Potential use of microRNA‑200c as a prognostic marker in non‑small cell lung cancer". Oncology Letters 14, no. 4 (2017): 4325-4330. https://doi.org/10.3892/ol.2017.6667