Open Access

Metastasis-associated in colon cancer 1: A promising biomarker for the metastasis and prognosis of colorectal cancer (Review)

  • Authors:
    • He Li
    • Yi‑Xin Chen
    • Jia‑Gen Wen
    • Hong‑Hao Zhou
  • View Affiliations

  • Published online on: July 26, 2017     https://doi.org/10.3892/ol.2017.6670
  • Pages: 3899-3908
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Colorectal cancer (CRC) is the fourth most frequent type of malignancy in the world. Metastasis accounts for >90% mortalities in patients with CRC. The metastasis‑associated in colon cancer 1 (MACC1) gene has been identified as a novel biomarker for the prediction of metastasis and disease prognosis, particularly for patients with early‑stage disease. Previous clinical studies demonstrated that MACC1 expression and polymorphisms in CRC tissues were indicators of metastasis, and that circulating transcripts in plasma were also significantly associated with the survival of patients. The present review describes the use of MACC1 beyond its utility in the clinic. By elucidating the upstream and downstream signal pathways of MACC1, the well‑known mechanisms of MACC1‑mediated cell proliferation, invasion, migration and epithelial‑mesenchymal transition (EMT) are summarized, as well as the potential signaling pathways. Furthermore, the underlying mechanisms by which the overexpression of MACC1 causes cisplatin resistance are emphasized.
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October-2017
Volume 14 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Li H, Chen YX, Wen JG and Zhou HH: Metastasis-associated in colon cancer 1: A promising biomarker for the metastasis and prognosis of colorectal cancer (Review). Oncol Lett 14: 3899-3908, 2017
APA
Li, H., Chen, Y., Wen, J., & Zhou, H. (2017). Metastasis-associated in colon cancer 1: A promising biomarker for the metastasis and prognosis of colorectal cancer (Review). Oncology Letters, 14, 3899-3908. https://doi.org/10.3892/ol.2017.6670
MLA
Li, H., Chen, Y., Wen, J., Zhou, H."Metastasis-associated in colon cancer 1: A promising biomarker for the metastasis and prognosis of colorectal cancer (Review)". Oncology Letters 14.4 (2017): 3899-3908.
Chicago
Li, H., Chen, Y., Wen, J., Zhou, H."Metastasis-associated in colon cancer 1: A promising biomarker for the metastasis and prognosis of colorectal cancer (Review)". Oncology Letters 14, no. 4 (2017): 3899-3908. https://doi.org/10.3892/ol.2017.6670