Role of wild-type p53-induced phosphatase 1 in cancer (Review)

  • Authors:
    • Zhi‑Peng Wang
    • Ye Tian
    • Jun Lin
  • View Affiliations

  • Published online on: July 27, 2017     https://doi.org/10.3892/ol.2017.6685
  • Pages: 3893-3898
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Abstract

Wild-type p53-induced phosphatase (Wip1) is a member of the protein phosphatase type 2C family and is an established oncogene due to its dephosphorylation of several tumor suppressors and negative control of the DNA damage response system. It has been reported to dephosphorylate p53, ataxia telangiectasia mutated, checkpoint kinase 1 and p38 mitogen activated protein kinases, forming negative feedback loops to inhibit apoptosis and cell cycle arrest. Wip1 serves a major role in tumorigenesis, progression, invasion, distant metastasis and apoptosis in various types of human cancer. Therefore, it may be a potential biomarker and therapeutic target in the diagnosis and treatment of cancer. Furthermore, previous evidence has revealed a new role for Wip1 in the regulation of chemotherapy resistance. In the present review, the current knowledge on the role of Wip1 in cancer is discussed, as well as its potential as a novel target for cancer treatment and its function in chemotherapy resistance.
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October-2017
Volume 14 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Wang ZP, Tian Y and Lin J: Role of wild-type p53-induced phosphatase 1 in cancer (Review). Oncol Lett 14: 3893-3898, 2017
APA
Wang, Z., Tian, Y., & Lin, J. (2017). Role of wild-type p53-induced phosphatase 1 in cancer (Review). Oncology Letters, 14, 3893-3898. https://doi.org/10.3892/ol.2017.6685
MLA
Wang, Z., Tian, Y., Lin, J."Role of wild-type p53-induced phosphatase 1 in cancer (Review)". Oncology Letters 14.4 (2017): 3893-3898.
Chicago
Wang, Z., Tian, Y., Lin, J."Role of wild-type p53-induced phosphatase 1 in cancer (Review)". Oncology Letters 14, no. 4 (2017): 3893-3898. https://doi.org/10.3892/ol.2017.6685