Open Access

Leiomyosarcoma of the inferior vena cava: Survival rate following radical resection

  • Authors:
    • Frederico José Ribeiro Teixeira
    • Sergio Dias do Couto Netto
    • André Luis de Freitas Perina
    • Fabio C. M. Torricelli
    • Luciana Ragazzo Teixeira
    • Antonio Eduardo Zerati
    • Fabio de Oliveira Ferreira
    • Eduardo Hiroshi Akaishi
    • William Carlos Nahas
    • Edivaldo Massazo Utiyama
  • View Affiliations

  • Published online on: August 2, 2017     https://doi.org/10.3892/ol.2017.6706
  • Pages: 3909-3916
  • Copyright: © Teixeira et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Leiomyosarcoma (LMS) of inferior vena cava (IVC) is a rare neoplasm affecting approximately 1/100,000 people. The prognosis is poor and potential curative intent occurs through challenging operations, such as vena cava resection, occasionally multivisceral when required, and vascular reconstruction. There are few retrospective series regarding this retroperitoneal neoplasm, and the aim of the present study was to discuss the experience at the São Paulo Cancer Institute and Clinics Hospital of University of São Paulo Medical School, São Paulo, Brazil. The current study is a retrospective review of 7 patients treated in the two tertiary hospitals between 2005 and 2013. Oncological and operative aspects were discussed, primarily regarding surgical aspects highlighting en bloc resection, vascular reconstruction, and the overall survival and recurrence rates. All the patients were treated with radical intent, 4 of whom underwent multivisceral resection, with the kidney being the most resected organ. The location of the IVC tumor was described using Kulaylat's description and the median tumor size was 10 cm. Vascular reconstruction was necessary in 4 patients. The overall survival rate at 3 and 5 years was 100, and 25%, respectively. The disease‑free survival rate at 3 and 5 years was 57 and 20%, respectively. In conclusion, IVC LMS is a rare and severe retroperitoneal neoplasm, with multivisceral resections remaining a surgical challenge. The treatment requires numerous experienced surgeons and the impact of microscopic free margins remains unclear. Vascular reconstruction depends on several aspects regarding primarily the topography of the tumor.
View Figures
View References

Related Articles

Journal Cover

October-2017
Volume 14 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Teixeira FJ, do Couto Netto SD, Perina AL, Torricelli FC, Ragazzo Teixeira L, Zerati AE, Ferreira Fd, Akaishi EH, Nahas WC, Utiyama EM, Utiyama EM, et al: Leiomyosarcoma of the inferior vena cava: Survival rate following radical resection. Oncol Lett 14: 3909-3916, 2017
APA
Teixeira, F.J., do Couto Netto, S.D., Perina, A.L., Torricelli, F.C., Ragazzo Teixeira, L., Zerati, A.E. ... Utiyama, E.M. (2017). Leiomyosarcoma of the inferior vena cava: Survival rate following radical resection. Oncology Letters, 14, 3909-3916. https://doi.org/10.3892/ol.2017.6706
MLA
Teixeira, F. J., do Couto Netto, S. D., Perina, A. L., Torricelli, F. C., Ragazzo Teixeira, L., Zerati, A. E., Ferreira, F. d., Akaishi, E. H., Nahas, W. C., Utiyama, E. M."Leiomyosarcoma of the inferior vena cava: Survival rate following radical resection". Oncology Letters 14.4 (2017): 3909-3916.
Chicago
Teixeira, F. J., do Couto Netto, S. D., Perina, A. L., Torricelli, F. C., Ragazzo Teixeira, L., Zerati, A. E., Ferreira, F. d., Akaishi, E. H., Nahas, W. C., Utiyama, E. M."Leiomyosarcoma of the inferior vena cava: Survival rate following radical resection". Oncology Letters 14, no. 4 (2017): 3909-3916. https://doi.org/10.3892/ol.2017.6706