Open Access

Decreased expression of long non‑coding RNA LOC728290 in human hepatocellular carcinoma

  • Authors:
    • Shao‑Geng Zhang
    • Yu‑Feng Li
    • Na‑Na Zhao
    • Cheng‑Cai Lai
    • Si‑Jie Cheng
    • Jin Yan
    • Peirui Zhang
    • Zhaohai Wang
    • Xi‑Liang Wang
    • Peng‑Hui Yang
  • View Affiliations

  • Published online on: August 18, 2017     https://doi.org/10.3892/ol.2017.6776
  • Pages: 4551-4556
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Hepatocellular carcinoma (HCC) is a leading cause of cancer‑associated mortality worldwide. Despite progress in the diagnosis and treatment of HCC, prognosis remains unfavorable. Long non‑coding RNAs (lncRNAs) are emerging as important factors in tumorigenesis and cancer progression; however, the underlying molecular mechanisms and clinical significance of lncRNAs in HCC remain largely unknown. The present study examined the expression pattern and clinical significance of a novel lncRNA, LOC728290, in HCC. Expression of LOC728290 was markedly decreased in HCC tissues compared with adjacent non‑tumor liver tissues, as detected using the reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR). The area under the receiver operating characteristic curve for LOC728290 was 0.728. The expression of LOC728290 was associated with the level of α‑fetoprotein and microvascular invasion. Furthermore, patients with low LOC728290 expression exhibited decreased recurrence‑free survival times (P<0.05) compared with those with high LOC728290 expression. The results of the present study indicated that downregulation of LOC728290 in patients with HCC may be a powerful tumor biomarker, with potential clinical applications in prognosis as well as a therapeutic target.
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October-2017
Volume 14 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhang SG, Li YF, Zhao NN, Lai CC, Cheng SJ, Yan J, Zhang P, Wang Z, Wang XL, Yang PH, Yang PH, et al: Decreased expression of long non‑coding RNA LOC728290 in human hepatocellular carcinoma. Oncol Lett 14: 4551-4556, 2017
APA
Zhang, S., Li, Y., Zhao, N., Lai, C., Cheng, S., Yan, J. ... Yang, P. (2017). Decreased expression of long non‑coding RNA LOC728290 in human hepatocellular carcinoma. Oncology Letters, 14, 4551-4556. https://doi.org/10.3892/ol.2017.6776
MLA
Zhang, S., Li, Y., Zhao, N., Lai, C., Cheng, S., Yan, J., Zhang, P., Wang, Z., Wang, X., Yang, P."Decreased expression of long non‑coding RNA LOC728290 in human hepatocellular carcinoma". Oncology Letters 14.4 (2017): 4551-4556.
Chicago
Zhang, S., Li, Y., Zhao, N., Lai, C., Cheng, S., Yan, J., Zhang, P., Wang, Z., Wang, X., Yang, P."Decreased expression of long non‑coding RNA LOC728290 in human hepatocellular carcinoma". Oncology Letters 14, no. 4 (2017): 4551-4556. https://doi.org/10.3892/ol.2017.6776